{"id":2115,"date":"2021-03-10T02:49:46","date_gmt":"2021-03-09T18:49:46","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2115"},"modified":"2021-03-10T02:49:46","modified_gmt":"2021-03-09T18:49:46","slug":"the-important-role-of-14548-51-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2115","title":{"rendered":"The important role of 14548-51-7"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 14548-51-7, name is 7-Bromo-3,4-dihydroquinolin-2(1H)-one, belongs to quinolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14548-51-7, Product Details of 14548-51-7<\/a><\/p>\n

Pd(PPh3)4 (102 mg, 0.088 mmol) was added to a degassed solution of 7-bromo-3,4-dihydro-1H- quinolin-2-one (100 mg, 0.442 mmol), 1 ,3-dimethyl-5-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2- yl)pyridin-2-one (prepared using described procedure in U520130053362, 165 mg, 0.664 mmol), and C52CO3 (288 mg, 0.885 mmol) in DME (5 mL) and water (0.5 mL). The resulting mixture washeated to 80 C for 5 h and then cooled to rt. The mixture was diluted with saturated NaHCO3 (20 mL) and EtOAc (20 mL), and the aqueous phase was extracted with EtOAc (3 x 20 mL). The combined organic phases were dried over Mg504, filtered, and evaporated under reduced pressure. The material was purified by flash chromatography on silica gel using a mixture of DCM and MeOH as eluent to provide Intermediate 3 (56 mg, 47%). 1H NMR (500 MHz, MeOD) O 7.78(d, J = 2.5 Hz, 1H), 7.70 (dd, J = 2.5, 1.1 Hz, 1H), 7.24 (d, J = 7.8 Hz, 1H), 7.15 (dd, J = 7.8, 1.9 Hz, 1H), 6.98 (d, J = 1.8 Hz, 1H), 3.65 (5, 3H), 3.01 -2.94 (m, 2H), 2.62-2.56 (m, 2H), 2.22- 2.17 (m, 3H). MS (ESI) [M+H] 269.3.<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Bromo-3,4-dihydroquinolin-2(1H)-one, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Bromo-3,4-dihydroquinolin-2(1H)-one, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[432,427],"tags":[127],"class_list":["post-2115","post","type-post","status-publish","format-standard","hentry","category-14548-51-7","category-quinolines-derivatives","tag-m-w200-300"],"yoast_head":"\nThe important role of 14548-51-7<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 14548-51-7, name is 7-Bromo-3,4-dihydroquinolin-2(1H)-one, belongs to quinolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The important role of 14548-51-7","description":"Adding a certain compound to certain chemical reactions, such as: 14548-51-7, name is 7-Bromo-3,4-dihydroquinolin-2(1H)-one, belongs to quinolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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