{"id":2106,"date":"2021-03-09T03:21:55","date_gmt":"2021-03-08T19:21:55","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2106"},"modified":"2021-03-09T03:21:55","modified_gmt":"2021-03-08T19:21:55","slug":"simple-exploration-of-92933-47-6","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2106","title":{"rendered":"Simple exploration of 92933-47-6"},"content":{"rendered":"

These common heterocyclic compound, 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 92933-47-6<\/a><\/p>\n

General procedure: To a solution of HATU (104 mg, 0.27 mmol) and 3-isopropylpyrazole-5-carboxylic acid (36 mg, 0.22 mmol) in DMF (14 mL) was then added diisopropylethylamine (0.055 mL, 0.31 mmol). The reaction solution was stirred at room temperature for 2 h. 2-(Benzylamino)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carbonitrile (75 mg, 0.21 mmol) was added in one portion. The solution was then stirred at room temperature overnight. The reaction was diluted with methylene chloride and washed. The aqueous layer was extracted with methylene chloride twice, the combined organic phases were dried over anhydrous MgSO4. The resulting residue was purified by column chromatography on silica gel (EtOAc\/hexane = 2:1) to give title compound as a white solid (33 mg, 37%).<\/p>\n

The synthetic route of 5-Isopropyl-1H-pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 5-Isopropyl-1H-pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[352,131],"tags":[126],"class_list":["post-2106","post","type-post","status-publish","format-standard","hentry","category-92933-47-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSimple exploration of 92933-47-6<\/title>\n<meta name=\"description\" content=\"These common heterocyclic compound, 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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