{"id":2087,"date":"2021-03-09T03:21:16","date_gmt":"2021-03-08T19:21:16","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2087"},"modified":"2021-03-09T03:21:16","modified_gmt":"2021-03-08T19:21:16","slug":"the-important-role-of-151521-49-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2087","title":{"rendered":"The important role of 151521-49-2"},"content":{"rendered":"

Reference of 151521-49-2<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 151521-49-2 as follows.<\/p>\n

A mixture of methyl 3-oxo-3-(3-pyridyl)propanoate (100 mg, 558.12 muiotaetaomicron, 1 eq) and 4-isopropyl- 1H-pyrazol-5-amine (69.86 mg, 558.12 muiotaetaomicron, 1 eq) in AcOH (2 mL) was stirred at 120C for 0.5 h. The reaction mixture was concentrated under reduced pressure to give the crude product 3- isopropyl-5-(3-pyridyl)pyrazolo[l,5-a]pyrimidin-7-ol (120 mg, 471.91 muiotaetaomicron, 84.6% yield, crude purity) as brown oil which was used in the next step without further purification. MR (400 MHz, OMSO-de) delta ppm 9.47-8.95 (m, 1H), 8.80-8.70 (m, 1H), 8.30-8.20 (m, 1H), 7.87, 7.38 (m, 1H), 7.60-7.50 (m, 1H), 7.08, 1.24 (d, J = 6.8 Hz, 3H), 1.07 (dd, J = 3.5, 6.8 Hz, 3H); ES-LCMS m\/z 255.1 [M+H].<\/p>\n

According to the analysis of related databases, 151521-49-2, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 151521-49-2, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[422,131],"tags":[126],"class_list":["post-2087","post","type-post","status-publish","format-standard","hentry","category-151521-49-2","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of 151521-49-2<\/title>\n<meta name=\"description\" content=\"Reference of 151521-49-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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