{"id":2064,"date":"2021-03-08T05:23:37","date_gmt":"2021-03-07T21:23:37","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2064"},"modified":"2021-03-08T05:23:37","modified_gmt":"2021-03-07T21:23:37","slug":"discovery-of-5932-30-9","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2064","title":{"rendered":"Discovery of 5932-30-9"},"content":{"rendered":"

Electric Literature of 5932-30-9<\/a>, A common heterocyclic compound, 5932-30-9, name is Ethyl 5-phenyl-1H-pyrazole-3-carboxylate, molecular formula is C12H12N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

General procedure: Compound ethyl 1H-indole-2-carboxylate (0.1g, 0.53 mmol) was added to a solution of 6h (0.29 g, 2.6 mmol) in EtOH (10 mL) at ambient temperature. The reaction was refluxed for 6 h and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to yield the target product 1. (yield: 77%). 1H NMR (400 MHz, DMSO-d6) delta 11.74 (s, 1H), 11.44 (s, 1H), 7.66 (t, J = 6.3 Hz, 2H), 7.45 (d, J = 8.3 Hz, 1H), 7.35 – 7.11 (m, 2H), 7.06 (t, J = 7.6 Hz, 1H), 2.28 (s, 1H), 1.87 – 1.60 (m, 3H), 1.38 – 1.21 (m, 7H). 13C NMR (400 MHz, DMSO-d6) delta 157.90, 130.67, 127.46, 124.06, 122.10, 112.79, 103.54, 30.22, 29.13, 28.12. HRMS(ESI) m\/z calculated for C16H19N3O [M+Na]+:292.1426, found 292.1420.<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[419,131],"tags":[127],"class_list":["post-2064","post","type-post","status-publish","format-standard","hentry","category-5932-30-9","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nDiscovery of 5932-30-9<\/title>\n<meta name=\"description\" content=\"Electric Literature of 5932-30-9, A common heterocyclic compound, 5932-30-9, name is Ethyl 5-phenyl-1H-pyrazole-3-carboxylate, molecular formula is C12H12N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=2064\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Discovery of 5932-30-9\" \/>\n<meta property=\"og:description\" content=\"Electric Literature of 5932-30-9, A common heterocyclic compound, 5932-30-9, name is Ethyl 5-phenyl-1H-pyrazole-3-carboxylate, molecular formula is C12H12N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=2064\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-07T21:23:37+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2064\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2064\",\"name\":\"Discovery of 5932-30-9\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-03-07T21:23:37+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Electric Literature of 5932-30-9, A common heterocyclic compound, 5932-30-9, name is Ethyl 5-phenyl-1H-pyrazole-3-carboxylate, molecular formula is C12H12N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2064#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=2064\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2064#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Discovery of 5932-30-9\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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