{"id":2062,"date":"2021-03-08T05:23:37","date_gmt":"2021-03-07T21:23:37","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2062"},"modified":"2021-03-08T05:23:37","modified_gmt":"2021-03-07T21:23:37","slug":"application-of-175137-46-9-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2062","title":{"rendered":"Application of 175137-46-9"},"content":{"rendered":"<p><a href=\"https:\/\/www.ambeed.com\/products\/175137-46-9.html\">Reference of 175137-46-9<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 175137-46-9 as follows.<\/p>\n<p>A solution of 4-chloro-2-methylsulfanyl-5, 8-dihydro-6H-pyrido [3, 4-d] pyrimidine-7- carboxylic acid benzyl ester (Method 147; 5.0 g, 14.0 mmol), triethylamine (4.3 g, 43 mmol), and5-cyclopropyl-lH-pyrazol-3-ylamine (2.6 g, 21 mmol) in NMP (30ml) was heated at 110 C for 48 hours. After cooling to25 C, the reaction was diluted with H20 (30 ml), extracted with MTBE (4 x 50 ml). The combined organic layer was dried overMgS04, concentrated, and purified by column chromatography (DCM:MeOH = 50 :1) to give the title compound (2.5 g, 40%). MS: Calcd.: 436; Found: [M+H] + 437.<\/p>\n<p>According to the analysis of related databases, 175137-46-9, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>According to the analysis of related databases, 175137-46-9, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[189,131],"tags":[126],"class_list":["post-2062","post","type-post","status-publish","format-standard","hentry","category-175137-46-9","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Application of 175137-46-9<\/title>\n<meta name=\"description\" content=\"Reference of 175137-46-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 175137-46-9 as follows.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=2062\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Application of 175137-46-9\" \/>\n<meta property=\"og:description\" content=\"Reference of 175137-46-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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An updated downstream synthesis route of 175137-46-9 as follows.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=2062","og_locale":"en_US","og_type":"article","og_title":"Application of 175137-46-9","og_description":"Reference of 175137-46-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 175137-46-9 as follows.","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=2062","og_site_name":"pyrazoles-derivatives","article_published_time":"2021-03-07T21:23:37+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=2062","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=2062","name":"Application of 175137-46-9","isPartOf":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2021-03-07T21:23:37+00:00","author":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"Reference of 175137-46-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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