{"id":2060,"date":"2021-03-08T05:23:37","date_gmt":"2021-03-07T21:23:37","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2060"},"modified":"2021-03-08T05:23:37","modified_gmt":"2021-03-07T21:23:37","slug":"some-tips-on-52222-73-8-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2060","title":{"rendered":"Some tips on 52222-73-8"},"content":{"rendered":"

Reference of 52222-73-8<\/a>, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52222-73-8, name is 4-(Trifluoromethyl)-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.<\/p>\n

To a stirred suspension of 4-(trifluoromethyl)-1H-pyrazole (0.4 g, 2.93 mmol) in dry DMF (8 mL), Cs2CO3 (1.91 g, 5.87mmol) and tert-butyl 4-((methylsulfonyl)-oxy) piperidine-1-carboxylate (obtained as described in Step 1 of Intermediate 10, 1.23 g, 5.87 mmol) were added at 0 C. The reaction mixture was stirred at 80 C overnight, and the reaction mixture was diluted with water (10 mL). The product was extracted with EtOAc (2 x 10 mL). The combined organic layer was dried over anhydrous Na2S04 and concentrated under vacuum. The crude product was purified by flash chromatography on silica gel (230-400 mesh) to afford the title compound. Yield: 73% (0.69 g, pale brown solid). 1H NMR (400 MHz, DMSO-d6): delta 8.71 (s, 1 H), 7.90 (s, 1 H), 4.44 (q, J = 7.6 Hz, 1 H), 4.04-4.06 (m, 2H), 3.10-2.69 (m, 2H), 2.02-2.08 (d, 2H), 1.84-1.75 (m, 2H), 1.42 (s, 9H). LCMS: (Method A) 264.2 (M-56), Rt. 4.82 min, 91.18% (Max).<\/p>\n

The chemical industry reduces the impact on the environment during synthesis 4-(Trifluoromethyl)-1H-pyrazole. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"excerpt":{"rendered":"

The chemical industry reduces the impact on the environment during synthesis 4-(Trifluoromethyl)-1H-pyrazole. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[137,131],"tags":[126],"class_list":["post-2060","post","type-post","status-publish","format-standard","hentry","category-52222-73-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSome tips on 52222-73-8<\/title>\n<meta name=\"description\" content=\"Reference of 52222-73-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52222-73-8, name is 4-(Trifluoromethyl)-1H-pyrazole, This compound has unique chemical properties. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Some tips on 52222-73-8","description":"Reference of 52222-73-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52222-73-8, name is 4-(Trifluoromethyl)-1H-pyrazole, This compound has unique chemical properties. 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The synthetic route is as follows.","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=2060","og_site_name":"pyrazoles-derivatives","article_published_time":"2021-03-07T21:23:37+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=2060","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=2060","name":"Some tips on 52222-73-8","isPartOf":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2021-03-07T21:23:37+00:00","author":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"Reference of 52222-73-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52222-73-8, name is 4-(Trifluoromethyl)-1H-pyrazole, This compound has unique chemical properties. 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