{"id":2052,"date":"2021-03-08T05:23:37","date_gmt":"2021-03-07T21:23:37","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2052"},"modified":"2021-03-08T05:23:37","modified_gmt":"2021-03-07T21:23:37","slug":"a-new-synthetic-route-of-5334-40-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2052","title":{"rendered":"A new synthetic route of 5334-40-7"},"content":{"rendered":"

Some common heterocyclic compound, 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, molecular formula is C4H3N3O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C4H3N3O4<\/a><\/p>\n

4-(morpholinomethyl)-phenyl-1,2-diamine (2.3 g, 11.1 mmol), 4-nitro-1H-pyrazole-3-carboxylic acid (1.57 g, 10 mmol), EDC\u00a1\u00a4HCl (2.13 g, 11.1 mmol) and HOBt (1.5 g, 11.1 mmol) were dissolved in anhydrous DMF (25 mL). The solvent was removed under reduced pressure, was added glacial acetic acid (40 mL), heated to reflux for 3 hours, the solvent was removed under reduced pressure, and purified by column (CH2Cl2 \/ CH3OH (V \/ V) = 20\/1), and then washed with methanol (30mL) to give a solid (0.9g, 27percent).<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5334-40-7, its application will become more common.<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5334-40-7, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[153,131],"tags":[126],"class_list":["post-2052","post","type-post","status-publish","format-standard","hentry","category-5334-40-7","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nA new synthetic route of 5334-40-7<\/title>\n<meta name=\"description\" content=\"Some common heterocyclic compound, 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, molecular formula is C4H3N3O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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