{"id":2037,"date":"2021-03-08T05:22:26","date_gmt":"2021-03-07T21:22:26","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2037"},"modified":"2021-03-08T05:22:26","modified_gmt":"2021-03-07T21:22:26","slug":"simple-exploration-of-31108-57-3-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2037","title":{"rendered":"Simple exploration of 31108-57-3"},"content":{"rendered":"

Some common heterocyclic compound, 31108-57-3, name is 1H-Pyrazole-4-carbonitrile, molecular formula is C4H3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 1H-Pyrazole-4-carbonitrile<\/a><\/p>\n

To a solution of I-R15 (200 mg) in anhydrous THF (20 mL) was added lH-pyrazole-4- carbonitrile (90.9 mg, 1.0 mmol) and K2C03 (134 mg, 1.0 mmol) at 25C under N2. The mixture was stirred at 65C for 12 h. The reaction mixture was poured into ice-water (30 mL). The aqueous phase was extracted with EtOAc (2 x 50 mL). The combined organic phase was washed with saturated brine (2 x 50 mL), dried over anhydrous Na2S04, filtered and concentrated. The residue was purified by flash column (30-40% of EtOAc in PE) to give I-R16 (130 mg, 63%) as an oil. (2182) 1H NMR (400 MHz, CDCl3) dH 7.88 (s, 1H), 7.82 (s, 1H), 6.65 (s, 1H), 5.39-5.30 (m, 2H), 2.43 (dd, J= 6.0, 18.4 Hz, 1H), 2.16-2.07 (m, 1H), 2.00 (s, 1H), 1.97-1.49 (m, 7H), 1.43-0.99 (m, 17H), 0.96 (s, 3H).<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 31108-57-3, its application will become more common.<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 31108-57-3, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[326,131],"tags":[145],"class_list":["post-2037","post","type-post","status-publish","format-standard","hentry","category-31108-57-3","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nSimple exploration of 31108-57-3<\/title>\n<meta name=\"description\" content=\"Some common heterocyclic compound, 31108-57-3, name is 1H-Pyrazole-4-carbonitrile, molecular formula is C4H3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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