{"id":2025,"date":"2021-03-05T04:51:17","date_gmt":"2021-03-04T20:51:17","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2025"},"modified":"2021-03-05T04:51:17","modified_gmt":"2021-03-04T20:51:17","slug":"some-tips-on-1190380-49-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2025","title":{"rendered":"Some tips on 1190380-49-4"},"content":{"rendered":"

Related Products of 1190380-49-4<\/a>, The chemical industry reduces the impact on the environment during synthesis 1190380-49-4, name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, I believe this compound will play a more active role in future production and life.<\/p>\n

Into a 50-mL round-bottom flask, was placed 23.2 (100 mg, 0.27 mmol, 1.00 eq.), n-BuOH (10 mL), 1-(oxan-4-yl)-1H-pyrazol-4-amine (90 mg, 0.54 mmol, 2.01 eq.), and hydrogen chloride in dioxane (1 mL, 4 M). The resulting solution was stirred for 30 h at 110 C in an oil bath. The resulting mixture was concentrated in vacuo. The resulting solution was diluted with H20. The pH value of the solution was adjusted to 10 with sodium carbonate. The solids were collected by filtration. The crude product was purified by Flash- Prep-HPLC with the following conditions (IntelFlash-1): Column, C18; mobile phase, ACN_Water=0: l increasing to ACN_Water=l :0 within 15 min; Detector, UV 254 nm. This resulted in 15.6 mg (12%) of I-24 as a brown solid. LC-MS: (ESI, m\/z): [M+H+]= 505.3. 1H NMR: {4d-MeOD, ppm) 7.889 (1H, s), 7.590 (1H, s), 7.055-7.065 (1H, m), 6.050-6.060 (1H, m), 4.302-4.408 (1H, m), 4.054-4.171 (3H, m), 3.941-3.974 (3H, s), 3.528-3.615 (2H, m), 2.722-2.755 (4H, m), 2.539-2.607 (1H, m), 2.279-2.321 (2H, m), 2.047-2.174 (6H, m), 1.300- 1.700 (8H, m), 0.350 (4H, s).<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[210,131],"tags":[126],"class_list":["post-2025","post","type-post","status-publish","format-standard","hentry","category-1190380-49-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSome tips on 1190380-49-4<\/title>\n<meta name=\"description\" content=\"Related Products of 1190380-49-4, The chemical industry reduces the impact on the environment during synthesis 1190380-49-4, name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, I believe this compound will play a more active role in future production and life.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=2025\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Some tips on 1190380-49-4\" \/>\n<meta property=\"og:description\" content=\"Related Products of 1190380-49-4, The chemical industry reduces the impact on the environment during synthesis 1190380-49-4, name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, I believe this compound will play a more active role in future production and life.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=2025\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-04T20:51:17+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2025\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2025\",\"name\":\"Some tips on 1190380-49-4\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-03-04T20:51:17+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Related Products of 1190380-49-4, The chemical industry reduces the impact on the environment during synthesis 1190380-49-4, name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, I believe this compound will play a more active role in future production and life.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2025#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=2025\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=2025#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"http:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Some tips on 1190380-49-4\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"http:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/cn.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/cn.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Some tips on 1190380-49-4","description":"Related Products of 1190380-49-4, The chemical industry reduces the impact on the environment during synthesis 1190380-49-4, name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, I believe this compound will play a more active role in future production and life.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=2025","og_locale":"en_US","og_type":"article","og_title":"Some tips on 1190380-49-4","og_description":"Related Products of 1190380-49-4, The chemical industry reduces the impact on the environment during synthesis 1190380-49-4, name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, I believe this compound will play a more active role in future production and life.","og_url":"https:\/\/www.pyrazoles-derivatives.com\/?p=2025","og_site_name":"pyrazoles-derivatives","article_published_time":"2021-03-04T20:51:17+00:00","author":"Jessica.F","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jessica.F","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=2025","url":"https:\/\/www.pyrazoles-derivatives.com\/?p=2025","name":"Some tips on 1190380-49-4","isPartOf":{"@id":"http:\/\/www.pyrazoles-derivatives.com\/#website"},"datePublished":"2021-03-04T20:51:17+00:00","author":{"@id":"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1"},"description":"Related Products of 1190380-49-4, The chemical industry reduces the impact on the environment during synthesis 1190380-49-4, name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, I believe this compound will play a more active role in future production and life.","breadcrumb":{"@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=2025#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.pyrazoles-derivatives.com\/?p=2025"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.pyrazoles-derivatives.com\/?p=2025#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u9996\u9875","item":"http:\/\/www.pyrazoles-derivatives.com\/"},{"@type":"ListItem","position":2,"name":"Some tips on 1190380-49-4"}]},{"@type":"WebSite","@id":"http:\/\/www.pyrazoles-derivatives.com\/#website","url":"http:\/\/www.pyrazoles-derivatives.com\/","name":"pyrazoles-derivatives","description":"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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