{"id":2002,"date":"2021-03-04T05:13:16","date_gmt":"2021-03-03T21:13:16","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2002"},"modified":"2021-03-04T05:13:16","modified_gmt":"2021-03-03T21:13:16","slug":"extended-knowledge-of-1227611-94-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2002","title":{"rendered":"Extended knowledge of 1227611-94-0"},"content":{"rendered":"

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1227611-94-0 as follows. Product Details of 1227611-94-0<\/a><\/p>\n

Intermediate 28: 4-Iodo-1 -(1 -oxa-spiro[2.5]oct-6-yI)-1 H -pyrazole 2-Methyl-propan-2-ol potassium (466 mg; 4.15 mmol; 1.2 eq.) was added in one portion to a solution of 4-(4-Iodo-pyrazol-1-yI)-cyclohexanone (1.02 g; 3.50 mmol; 1.0 eq.) and trimethylsulfoxonium chloride (531 mg; 4.13 mmol; 1.2 eq.) in DMSO (50 mL). The reaction mixture was stirred at RT for 16 h. It was then poured into EtOAc . Organicphase was separated and washed with brine (three times), dried over magnesium sulfate, filtered and concentrated to give the title compound a white solid (813 mg, 76%).1H NMR (300 MHz, DMSO) oe8.01 (d, J = 0.5 Hz, 1H), 7.52 (d, J = 0.5 Hz, 1H), 4.41 -4.26(m, 1H), 2.66 (s, 2H), 2.13- 1.85 (m, 6H), 1.34- 1.21 (m, 2H). MS(ESI+): 305.1.<\/p>\n

According to the analysis of related databases, 1227611-94-0, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 1227611-94-0, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[403,131],"tags":[127],"class_list":["post-2002","post","type-post","status-publish","format-standard","hentry","category-1227611-94-0","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nExtended knowledge of 1227611-94-0<\/title>\n<meta name=\"description\" content=\"In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1227611-94-0 as follows. 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