{"id":2000,"date":"2021-03-04T05:13:16","date_gmt":"2021-03-03T21:13:16","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=2000"},"modified":"2021-03-04T05:13:16","modified_gmt":"2021-03-03T21:13:16","slug":"the-important-role-of-1904-31-0-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=2000","title":{"rendered":"The important role of 1904-31-0"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine, This compound has unique chemical properties. The synthetic route is as follows., Safety of 1-Methyl-1H-pyrazol-3-amine<\/a><\/p>\n

Step a) tert-butyl 1-(1 -hydro xy-2-(l -methyl- 1 H-pyrazol-3 -ylamino)-2-oxoethyl)- cyclobutylcarbamate (9-a)1 – Methyl- 1 H-pyrazol-3 -amine (158 mg, 1.63 mmol) and DIEA (1.08 mL, 6.52 mmol) was added to a solution of 2-(l-(teri-butoxycarbonylamino)cyclobutyl)-2-hydroxyacetic acid (400 mg, 1.63 mmol) dissolved in DMF (20 mL). The solution was cooled to 0 \u00a1\u00e3C and after 10 minutes HATU (620 mg, 1.63 mmol) was added. After approximately 2 hours at RT, LC-MS showed product and no starting material and the solvent was removed by rotary evaporation. The crude product was dissolved in 40 mL EtOAc and washed with 25 mL sat. NaHC03 (aq). The organic phase was dried with Na2S04, filtered and evaporated to dryness. The crude product was purified on a 25 g silica column on a Biotage Flashmaster, which gave the title product as a white solid (488 mg, 92percent).TLC rf: 0.07 in heptane:ethyl acetate 1 : 1. [M+H]+ = 325.<\/p>\n

According to the analysis of related databases, 1904-31-0, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 1904-31-0, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[219,131],"tags":[145],"class_list":["post-2000","post","type-post","status-publish","format-standard","hentry","category-1904-31-0","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nThe important role of 1904-31-0<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine, This compound has unique chemical properties. 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