{"id":1977,"date":"2021-03-03T05:06:35","date_gmt":"2021-03-02T21:06:35","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1977"},"modified":"2021-03-03T05:06:35","modified_gmt":"2021-03-02T21:06:35","slug":"some-scientific-research-about-2458-26-6-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1977","title":{"rendered":"Some scientific research about 2458-26-6"},"content":{"rendered":"

Application of 2458-26-6<\/a>,Some common heterocyclic compound, 2458-26-6, name is 3-Phenyl-1H-pyrazole, molecular formula is C9H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

At 0 C, a solution of 3-phenyl-1H-pyrazole (0.61 g, 5.3 mmol) in dry THF (10 mL) was added dropwise to a suspension of NaH (0.13 g,5.34 mmol) in dry THF (10 mL). After 15 min of stirring, a solution of 2,6-pyridine-dimethylene-ditosylate (1.20 g, 2.67 mmol) in dry THF (15 mL) was added to this solution; the mixture was stirred overnight and filtered, and the solvent was removed. The crude product was purified by column chromatography on silica gel with hexane:EA = 1:1 as eluent to afford 0.41 g (40%) of pure ligand as a white oil that solidified with time. Single crystals were obtained by slow diffusion of hexane into a concentrated solution of the ligand in THF at room temperature. 1H NMR (300 MHz, acetone-d6): 7.84(m, 2H, 4H, 5-H Pz, 2,6-H Ph), 7.65 (t, J = 7.8 Hz, 1H, 4-H Py), 7.36(t, J = 7.2 Hz, 4H, 3,5-H Ph), 7.26 (t, J = 7.5 Hz, 2H, 4-H Ph), 6.96 (d,J = 7.8 Hz, 2H, 3,5-H Py), 6.72 (d, J = 2.4 Hz, 2H, 4-H Pz), and 5.48 (s,4H, PyCH2Pz).13C NMR (75 MHz, acetone-d6): 157.9 (2C, 2,6-CPy), 152.2 (2C, 3-C Pz), 138.9 (1C, 4-C Py), 134.8 (2C, 1-C Ph), 132.9(2C, 5-C Pz), 129.3(4C, 3,5-C Ph), 128.2 (2C, 4-C Ph), 126.1 (4C, 2,6-CPh), 121.2 (2C, 3,5-C Py), 103.7 (2C, 4-C Pz), and 57.9 (2C, PyCH2Pz).<\/p>\n

The synthetic route of 2458-26-6 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 2458-26-6 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[164,131],"tags":[126],"class_list":["post-1977","post","type-post","status-publish","format-standard","hentry","category-2458-26-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSome scientific research about 2458-26-6<\/title>\n<meta name=\"description\" content=\"Application of 2458-26-6,Some common heterocyclic compound, 2458-26-6, name is 3-Phenyl-1H-pyrazole, molecular formula is C9H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=1977\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Some scientific research about 2458-26-6\" \/>\n<meta property=\"og:description\" content=\"Application of 2458-26-6,Some common heterocyclic compound, 2458-26-6, name is 3-Phenyl-1H-pyrazole, molecular formula is C9H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"http:\/\/www.pyrazoles-derivatives.com\/?p=1977\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-02T21:06:35+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=1977\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=1977\",\"name\":\"Some scientific research about 2458-26-6\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-03-02T21:06:35+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Application of 2458-26-6,Some common heterocyclic compound, 2458-26-6, name is 3-Phenyl-1H-pyrazole, molecular formula is C9H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=1977#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/www.pyrazoles-derivatives.com\/?p=1977\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=1977#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"http:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Some scientific research about 2458-26-6\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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