{"id":1965,"date":"2021-03-03T05:06:35","date_gmt":"2021-03-02T21:06:35","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1965"},"modified":"2021-03-03T05:06:35","modified_gmt":"2021-03-02T21:06:35","slug":"extracurricular-laboratory-synthetic-route-of-15802-80-9","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1965","title":{"rendered":"Extracurricular laboratory: Synthetic route of 15802-80-9"},"content":{"rendered":"

Synthetic Route of 15802-80-9<\/a>, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 15802-80-9, name is 3-(tert-Butyl)pyrazole, This compound has unique chemical properties. The synthetic route is as follows.<\/p>\n

EXAMPLE 4 Preparation of 5-[3-(1,1-dimethylethyl)-1H-pyrazol-1-yl]-3-[3-(trifluoromethyl)phenyl]-4-oxazolidinone To a solution of 5-hydroxy-3-[3-(trifluoromethyl)phenyl]-4-oxazolidinone (1 g, 4.05 mmol) in tetrahydrofuran (20 mL) under nitrogen at ~0 C., were added 3-(1,1-dimethylethyl)-1H-pyrazole (0.5 g, 4.05 mmol), triphenylphosphine (1.23 g, 4.7 mmol) and diisopropyl azodicarboxylate (0.88 mL, 4.46 mmol). After the addition, the reaction mixture was allowed to warm up slowly to room temperature and stirred at room temperature overnight. The reaction mixture was then concentrated, and the residue was purified by column chromatography (silica gel, ~20% ethylacetate\/80% hexanes) to give a crude product. The crude product was further purified by column chromatography (silica gel, ~20% ethyl acetate\/~80% hexanes) to give the title compound, a compound of this invention, as a white solid (14 mg) melting at 95-98 C. 1H NMR (CDCl3): delta 1.26 (s, 9H), 5.57 (d, 1H), 5.79 (d, 1H), 6.08 (s, 1H), 6.20 (d, 1H), 7.45-7.6 (m, 3H), 7.8-7.9 (m, 2H).<\/p>\n

The chemical industry reduces the impact on the environment during synthesis 3-(tert-Butyl)pyrazole. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"excerpt":{"rendered":"

The chemical industry reduces the impact on the environment during synthesis 3-(tert-Butyl)pyrazole. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[398,131],"tags":[126],"class_list":["post-1965","post","type-post","status-publish","format-standard","hentry","category-15802-80-9","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nExtracurricular laboratory: Synthetic route of 15802-80-9<\/title>\n<meta name=\"description\" content=\"Synthetic Route of 15802-80-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 15802-80-9, name is 3-(tert-Butyl)pyrazole, This compound has unique chemical properties. The synthetic route is as follows.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=1965\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Extracurricular laboratory: Synthetic route of 15802-80-9\" \/>\n<meta property=\"og:description\" content=\"Synthetic Route of 15802-80-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 15802-80-9, name is 3-(tert-Butyl)pyrazole, This compound has unique chemical properties. 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