{"id":1956,"date":"2021-03-02T05:18:48","date_gmt":"2021-03-01T21:18:48","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1956"},"modified":"2021-03-02T05:18:48","modified_gmt":"2021-03-01T21:18:48","slug":"analyzing-the-synthesis-route-of-13745-59-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1956","title":{"rendered":"Analyzing the synthesis route of 13745-59-0"},"content":{"rendered":"

Synthetic Route of 13745-59-0<\/a>, These common heterocyclic compound, 13745-59-0, name is 3-Bromo-1,4-dimethyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

To a solution of 246.la (lOg, 3.36mmol, 1.Oeq) and 3-bromo-1,4-dimethyl-1H-pyrazole (0.58g, 3.36mmol, 1.Oeq) in mixture of 1,4-dioxane (8.OmL) and water (2.OmL), potassium carbonate (1 .24g, 9.O2mmol, 2.5eq) was added. Argon waspurged through the reaction mixture for 5 mm. Then, [1,1?-bi s(diphenylphosphino)ferrocene] dichloropalladium(II) complex with CH2C12 (0 .29g, 0.33 mmol, 0. leq) was added and again purged for 5 mm. Reaction mixture was stirred at 110 C for 2h. After completion of the reaction, the reaction mixture was transferred to water and extracted with ethyl acetate. Organic layers were combined, dried over anhydrous Na2SO4, filtered and concentrated in vacuo to get the crude material. This was purified by column chromatography using 12% ethyl acetate in hexane as eluant to obtain 246.1 (0.6g, 39.35%). MS(ES): m\/z 266.38 [M+H]t<\/p>\n

Statistics shows that 3-Bromo-1,4-dimethyl-1H-pyrazole is playing an increasingly important role. we look forward to future research findings about 13745-59-0.<\/p>\n","protected":false},"excerpt":{"rendered":"

Statistics shows that 3-Bromo-1,4-dimethyl-1H-pyrazole is playing an increasingly important role. we look forward to future research findings about 13745-59-0.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[396,131],"tags":[126],"class_list":["post-1956","post","type-post","status-publish","format-standard","hentry","category-13745-59-0","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nAnalyzing the synthesis route of 13745-59-0<\/title>\n<meta name=\"description\" content=\"Synthetic Route of 13745-59-0, These common heterocyclic compound, 13745-59-0, name is 3-Bromo-1,4-dimethyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1956\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Analyzing the synthesis route of 13745-59-0\" \/>\n<meta property=\"og:description\" content=\"Synthetic Route of 13745-59-0, These common heterocyclic compound, 13745-59-0, name is 3-Bromo-1,4-dimethyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1956\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-01T21:18:48+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1956\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1956\",\"name\":\"Analyzing the synthesis route of 13745-59-0\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-03-01T21:18:48+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Synthetic Route of 13745-59-0, These common heterocyclic compound, 13745-59-0, name is 3-Bromo-1,4-dimethyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1956#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=1956\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1956#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Analyzing the synthesis route of 13745-59-0\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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