{"id":1946,"date":"2021-03-02T05:18:48","date_gmt":"2021-03-01T21:18:48","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1946"},"modified":"2021-03-02T05:18:48","modified_gmt":"2021-03-01T21:18:48","slug":"sources-of-common-compounds-1150271-23-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1946","title":{"rendered":"Sources of common compounds: 1150271-23-0"},"content":{"rendered":"

Some common heterocyclic compound, 1150271-23-0, name is tert-Butyl 4-bromo-1H-pyrazole-1-carboxylate, molecular formula is C8H11BrN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 1150271-23-0<\/a><\/p>\n

Add 1-Boc-4-bromopyrazole (24.7 g, 0.1 mol), bis(pinacolato)diboron (25.4 g, 0.1 mol) and catalyst [1,1′-bis (diphenylphosphino) ferrocene ] Palladium dichloride (0.74 g, 0.001 mol), potassium acetate (19.6 g, 0.2 mol), 200 ml of ethanol were added to the reaction bottle, and after removing the oxygen under reduced pressure, the nitrogen was heated to reflux, and the reaction was held for 16 hours. After monitoring the reaction of the raw materials, the filtrate was filtered. The filtrate was distilled off ethanol under reduced pressure. The residue was extracted with petroleum ether and purified to obtain 24.2 g of 1-Boc-4-pyrazoleboronic acid pinacol ester with a yield of 82.3%.<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1150271-23-0, its application will become more common.<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1150271-23-0, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[394,131],"tags":[127],"class_list":["post-1946","post","type-post","status-publish","format-standard","hentry","category-1150271-23-0","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nSources of common compounds: 1150271-23-0<\/title>\n<meta name=\"description\" content=\"Some common heterocyclic compound, 1150271-23-0, name is tert-Butyl 4-bromo-1H-pyrazole-1-carboxylate, molecular formula is C8H11BrN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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