{"id":1936,"date":"2021-03-01T05:11:03","date_gmt":"2021-02-28T21:11:03","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1936"},"modified":"2021-03-01T05:11:03","modified_gmt":"2021-02-28T21:11:03","slug":"continuously-updated-synthesis-method-about-131797-35-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1936","title":{"rendered":"Continuously updated synthesis method about 131797-35-8"},"content":{"rendered":"

131797-35-8, name is 5-Chloro-3-(trifluoromethyl)-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C4H2ClF3N2<\/a><\/p>\n

To a solution of 3-bromo-2-chloro-7-(chloromethyl)-5H-[l,3]thiazolo[3,2-a]pyrimidin-5-one (500 mg, 1.59 mmol) in acetonitrile (10 mL) was added 5-chloro-3-(trifluoromethyl)-lH-pyrazole (327 mg, 1.92 mmol), potassium iodide (133 mg, 0.80 mmol), and potassium carbonate (442 mg, 3.20 mmol) The resulting solution was stirred for 2 h at 80 C and cooled. The solid was filtered off and the filtrate was concentrated in vacuo. The residue was purified by flash chromatography on silica gel eluting with ethyl acetate\/petroleum ether (1\/9) to afford 3-bromo-2-chloro-7-(chloromethyl)-5H-[l,3]thiazolo[3,2- a]pyrimidin-5-one as a brown solid ( 300 mg, 60%). LCMS (ESI): M+H+ = 448.0.<\/p>\n

The synthetic route of 131797-35-8 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 131797-35-8 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[220,131],"tags":[126],"class_list":["post-1936","post","type-post","status-publish","format-standard","hentry","category-131797-35-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nContinuously updated synthesis method about 131797-35-8<\/title>\n<meta name=\"description\" content=\"131797-35-8, name is 5-Chloro-3-(trifluoromethyl)-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 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