{"id":1935,"date":"2021-03-01T05:11:03","date_gmt":"2021-02-28T21:11:03","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1935"},"modified":"2021-03-01T05:11:03","modified_gmt":"2021-02-28T21:11:03","slug":"research-on-new-synthetic-routes-about-1904-31-0-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1935","title":{"rendered":"Research on new synthetic routes about 1904-31-0"},"content":{"rendered":"

Electric Literature of 1904-31-0<\/a>, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.<\/p>\n

2-Bromopyridine (1 ) (1 .0g, 6.3mmol), 1 -methyl-1 H-pyrazol-3-amine (2) (0.79g, 8.2mmol), Xantphos (0.37g, 0.63mmol), and Cs2C03 (4.1 g, 12.6mmol) were combined in dry 1 ,4-dioxane (15mL). The reaction mixture was then degassed with N2(g), and placed under vacuum for 10min. Pd2(dba)3 (0.29g, 0.31 mmol) was added and the resulting reaction mixture was heated at 90\u00a1\u00e3C for 30h. It was then poured onto demineralized water (200ml_), and extracted with EtOAc (3 x 100ml_). The organic phases were combined, dried over Na2S04, filtered and subsequently concentrated in vacuo. The resulting residue was purified by flash chromatography with EtOAc\/Hexane (1 : 1 ) to provide N-(1 -methyl-1 H-pyrazol-3- yl)pyridin-2-amine (3) as a yellow solid (0.75g, 68percent). LCMS (ES): Found 175.2 [M+H]+.<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-pyrazol-3-amine, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-pyrazol-3-amine, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[219,131],"tags":[145],"class_list":["post-1935","post","type-post","status-publish","format-standard","hentry","category-1904-31-0","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nResearch on new synthetic routes about 1904-31-0<\/title>\n<meta name=\"description\" content=\"Electric Literature of 1904-31-0, In the next few decades, the world population will flourish. 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