{"id":1926,"date":"2021-03-01T05:11:03","date_gmt":"2021-02-28T21:11:03","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1926"},"modified":"2021-03-01T05:11:03","modified_gmt":"2021-02-28T21:11:03","slug":"simple-exploration-of-1246471-38-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1926","title":{"rendered":"Simple exploration of 1246471-38-4"},"content":{"rendered":"

1246471-38-4, name is Ethyl 3-Cyclopropylpyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 1246471-38-4<\/a><\/p>\n

To a solution of 4,4,5,5-tetramethyl-2-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1,3,2-dioxaborolane (1.03 g, 2.45 mmol) in pyridine (5 mL) were added ethyl 3-cyclopropyl-1H-pyrazol-4-carboxylate (0.53 g, 2.94 mmol) and copper(II) acetate monohydrate (0.25 g, 1.23 mmol), and the mixture was stirred overnight at 55C. The reaction mixture was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate_hexane=1:4) to give ethyl 3-cyclopropyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxylate (990 mg, yield 86%) as a solid and ethyl 5-cyclopropyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxylate (20 mg, yield 2%) as an oil. ethyl 3-cyclopropyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxylate (Reference Example 26) 1H-NMR (CDCl3) delta: 1.00-1.10 (2 H, m), 1.10-1.18 (2 H, m), 1.39 (3 H, t, J = 7.2 Hz), 2.57-2.70 (1 H, m), 4.29 (2 H, s), 4.35 (2 H, q, J = 7.2 Hz), 7.02 (1 H, s), 7.33-7.41 (2 H, m), 7.41-7.56 (3 H, m), 7.56-7.64 (2 H, m), 8.41 (1 H, s). ethyl 5-cyclopropyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxylate (Reference Example 27) 1H-NMR (CDCl3) delta: 0.59-0.71 (2 H, m), 0.77-0.91 (2 H, m), 1.32-1.45 (3 H, m), 1.88-2.01 (1 H, m), 4.22-4.39 (4 H, m), 7.08 (1 H, s), 7.30-7.56 (6 H, m), 7.74 (1 H, d, J = 8.0 Hz), 8.07 (1 H, s).<\/p>\n

The synthetic route of 1246471-38-4 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 1246471-38-4 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[392,131],"tags":[126],"class_list":["post-1926","post","type-post","status-publish","format-standard","hentry","category-1246471-38-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSimple exploration of 1246471-38-4<\/title>\n<meta name=\"description\" content=\"1246471-38-4, name is Ethyl 3-Cyclopropylpyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 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