{"id":1921,"date":"2021-02-26T05:09:18","date_gmt":"2021-02-25T21:09:18","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1921"},"modified":"2021-02-26T05:09:18","modified_gmt":"2021-02-25T21:09:18","slug":"share-a-compound-1134-50-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1921","title":{"rendered":"Share a compound : 1134-50-5"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 1134-50-5, name is 1-Phenyl-1H-pyrazole-4-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1134-50-5, category: pyrazoles-derivatives<\/a><\/p>\n

Procedure: The pyrazole is solubilized in DMF in a reactor under nitrogen and with magnetic stirring. CDI is then rapidly added in a single portion and the mixture is kept stirring for approximately 20 minutes. The amine is then rapidly added dropwise by means of a syringe. After stirring for 3 h 30 min, TLC monitoring of the reaction indicates that the starting product has completely disappeared. The reaction medium is then poured into 80 ml of an ice\/water mixture. The white precipitate formed after stirring for 15 minutes is then recovered by filtration through a sintered glass filter and dried by suction. The orangey solid obtained is then taken up in 50 ml of dichloromethane, washed once with water, and dried over sodium sulfate. After filtration through sintered glass filter and evaporation under partial vacuum, 0.8 g of a yellow solid is thus obtained. The latter is chromatographed on silica (elution: 7\/3 hexane\/ethyl acetate) and then recrystallized from toluene. 0.80 g of a beige solid is thus recovered (yield: 56%). It is characterized in the form of a compound associated with half a molecule of water.<\/p>\n

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"excerpt":{"rendered":"

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[155,131],"tags":[126],"class_list":["post-1921","post","type-post","status-publish","format-standard","hentry","category-1134-50-5","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nShare a compound : 1134-50-5<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 1134-50-5, name is 1-Phenyl-1H-pyrazole-4-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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