{"id":1918,"date":"2021-02-26T05:09:18","date_gmt":"2021-02-25T21:09:18","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1918"},"modified":"2021-02-26T05:09:18","modified_gmt":"2021-02-25T21:09:18","slug":"the-origin-of-a-common-compound-about-52222-73-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1918","title":{"rendered":"The origin of a common compound about 52222-73-8"},"content":{"rendered":"

52222-73-8, name is 4-(Trifluoromethyl)-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C4H3F3N2<\/a><\/p>\n

55 mg of 2-[3-(ethylsulphonyl)-6-fluoropyridin-2-yl]-1-methyl-5-(trifluoromethyl)-1H-benzimidazole (0.14 mmol) were dissolved in 2 ml of acetonitrile. 29 mg (0.21 mmol) of 4-(trifluoromethyl)-1H-pyrazole and 59 mg (0.42 mmol) of potassium carbonate were added and stirred for 3 h at room temperature. The mixture was filtered, concentrated and purified by column chromatography with a cyclohexane\/ethyl acetate gradient as mobile phase. log P (neutral): 4.16; MH+: 504; 1H-NMR (400 MHz, D6-DMSO) delta ppm: 9.38 (s, 1H), 8.712 (d, 1H), 8.46 (s, 1H), 8.42 (d, 1H), 8.16 (s, 1H), 7.98 (d, 1H), 7.70 (dd, 1H), 3.906 (q, 2H), 3.90 (s, 3H), 1.24 (t, 3H).<\/p>\n

The synthetic route of 52222-73-8 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 52222-73-8 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[137,131],"tags":[126],"class_list":["post-1918","post","type-post","status-publish","format-standard","hentry","category-52222-73-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe origin of a common compound about 52222-73-8<\/title>\n<meta name=\"description\" content=\"52222-73-8, name is 4-(Trifluoromethyl)-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 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