{"id":1902,"date":"2021-02-26T05:09:18","date_gmt":"2021-02-25T21:09:18","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1902"},"modified":"2021-02-26T05:09:18","modified_gmt":"2021-02-25T21:09:18","slug":"analyzing-the-synthesis-route-of-59340-27-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1902","title":{"rendered":"Analyzing the synthesis route of 59340-27-1"},"content":{"rendered":"<p>Adding a certain compound to certain chemical reactions, such as: 59340-27-1, name is 1,3,5-Trimethyl-1H-pyrazole-4-sulfonyl chloride, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound  59340-27-1, <a href=\"https:\/\/www.ambeed.com\/products\/59340-27-1.html\">Application In Synthesis of  1,3,5-Trimethyl-1H-pyrazole-4-sulfonyl chloride<\/a><\/p>\n<p>Example 1 4-(3,4-Dichlorophenoxy)-1-((1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl)piperidine 4-(3,4-Dichlorophenoxy)piperidine hydrochloride (143 mg, 0.508 mmol) (prepared as described for 4-(4-chloro-3-fluorophenoxy)piperidine hydrochloride (Intermediate 10) using 3,4-dichlorophenol) and triethylamine (142 muL, 1.16 mmol) in dichloromethane (10 mL) was treated with 1,3,5-trimethyl-1H-pyrazole-4-sulfonyl chloride (106 mg, 0.508 mmol). The reaction was stirred for 2 hours at room temperature. The crude reaction was washed with 1N hydrochloric acid, filtered through a phase separation cartridge and concentrated in vacuo. The crude product was purified by silica column chromatography eluting with petrol\/ethyl acetate to give the title compound. (160 mg, 76%) 1H NMR (400 MHz, DMSO-d6) delta ppm 1.62-1.75 (m, 2H) 2.00-2.15 (m, 2H) 2.30 (s, 3H) 2.45 (s, 3H) 2.78-2.86 (m, 2H) 3.34-3.42 (m, 2H) 3.75 (s, 3H) 4.45-4.54 (m, 1H) 6.95-6.98 (m, 1H) 7.28 (s, 1H) 7.24 (m, 1H) MS ES+: 419.<\/p>\n<p>If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[212,131],"tags":[127],"class_list":["post-1902","post","type-post","status-publish","format-standard","hentry","category-59340-27-1","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Analyzing the synthesis route of 59340-27-1<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 59340-27-1, name is 1,3,5-Trimethyl-1H-pyrazole-4-sulfonyl chloride, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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