{"id":1892,"date":"2021-02-25T05:13:18","date_gmt":"2021-02-24T21:13:18","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1892"},"modified":"2021-02-25T05:13:18","modified_gmt":"2021-02-24T21:13:18","slug":"introduction-of-a-new-synthetic-route-about-3920-50-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1892","title":{"rendered":"Introduction of a new synthetic route about 3920-50-1"},"content":{"rendered":"

Synthetic Route of 3920-50-1<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3920-50-1 as follows.<\/p>\n

A mixture of 2-(4-{[2-amino-5-chloro-4-(trifluoromethyl)phenyl]amino}phenyl)ethanol (step 2 of Example 104, 2.28 g, 5.85 mmol) and 1H-pyrazole-3-carbaldehyde (562 mg, 2.85 mmol) in ethanol (35 ml) was stirred under reflux temperature for 1 h. The mixture was concentrated and dissolved in benzene (40 ml). To this solution was added lead tetraacetate (2.85 g, 6.44 mmol) at rt. After stirring at room temperature for 18 h, to the mixture were added saturated aqueous sodium hydrogencarbonate (50 ml) and ethyl acetate. The organic layer was separated and washed with brine, dried (Na2SO4) and concentrated. Purification by flash column chromatography eluting with dichloromethane\/methanol (20:1 to 10:1), then dichloromethane\/2-propanol (5:1) afforded 979 mg (41percent) of the title compound as a slight brown solid. [2276] 1H-NMR (CDCl3\/CD3OD=4\/1) delta: 8.12 (1H, br.s), 7.74 (1H, s), 7.59 (1H, br.s), 7.47 (2H, d, J=7.9 Hz), 7.34-7.30 (3H, m), 6.36 (1H, br.s), 3.87 (2H, br.t, J=6.8 Hz), 2.95 (2H, t, J=6.8 Hz). MS (ESI) m\/z: 407 (MH+), 405 ([M-H]-).<\/p>\n

According to the analysis of related databases, 3920-50-1, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 3920-50-1, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[156,131],"tags":[145],"class_list":["post-1892","post","type-post","status-publish","format-standard","hentry","category-3920-50-1","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nIntroduction of a new synthetic route about 3920-50-1<\/title>\n<meta name=\"description\" content=\"Synthetic Route of 3920-50-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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