{"id":1884,"date":"2021-02-25T05:13:18","date_gmt":"2021-02-24T21:13:18","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1884"},"modified":"2021-02-25T05:13:18","modified_gmt":"2021-02-24T21:13:18","slug":"the-origin-of-a-common-compound-about-25016-20-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1884","title":{"rendered":"The origin of a common compound about 25016-20-0"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25016-20-0, name is 1-Methyl-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C5H6N2O2<\/a><\/p>\n

C2-Ocyclopropyl Boc protected amine macrocycle Am (75 mg, 0.093 mmol) is charged in a vial, then a 4 M solution of HCI in dioxane (1 ml_, 4 mmol) is added. The solution is stirred at RT for 1 .5 h, after which a precipitate forms. The solution is evaporated to dryness. 1 -methyl-1 H-pyrazole-3-carboxylic acid R2b (14.0 mg, 0.1 1 1 mmol) is dissolved in DCM (2 ml_), then TEA (51 .6 muIota_, 0.370 mmol) is added followed by TBTU (35.7 mg, 0.1 1 1 mmol). The solution is stirred for 15 mins, after which it is added to the amine hydrochloride in solution in DCM (1 ml_). The solution is stirred at RT for 16 h. The reaction is not complete so additional 1 -methyl-1 H pyrazole-3-carboxylic Acid R2b (3.5 mg, 0.028 mmol), TEA (13.0 muIota_, 0.092 mmol) followed by TBTU (8.9 mg, 0.028 mmol) are added. The solution is stirred at RT for 5 h, concentrated and then the residual is dissolved in DMSO. The resulting solution is filtered through a Millex filter and purified by prep HPLC (Sunfire column, ammonium formate and MeOH). The pure fractions are combined, concentrated, redissolved in MeCN and water, frozen and lyophilized to provide compound 1028. FIA M.S.(electrospray) : 818.4 (M+H)+ Retention time (min) = 5.5 min1H NMR (400 MHz,DMSO-d6): delta 10.80 (bs, 1 H), 8.93 (s, 1 H), 7.84 (d, 1 H, J = 8.9 Hz), 7.76 (d, 1 H, J = 2.4 Hz), 6.74-7.70 (m, 1 Hz), 7.10 (d, 1 H, J = 9.2 Hz), 6.59 (d, 1 H, J = 2.1 Hz), 6.38 (s, 1 H), 5.68-5.54 (m, 1 H), 5.47-5.40 (m, 1 H), 5.10-5.00 (m, 1 H), 4.68-4.56 (m 1 H), 4.50 (qn, 1 H, J = 3.2 Hz) 4.47-4.38 (m, 2H), 4.08-3.96 (m, 1 H), 3.89 (s, 3H), 3.88 (s, 3H), 2.66-2.58 (m, 1 H), 2.47 (s, 3H), 2.40-2.28 (m, 2H), 2.01 -1 .74 (m, 2H), 1 .64-1 .49 (m, 3H), 1 .48-1 .13 (m, 12H), 0.93-0.79 (m, 4H), 0.76- 0.69 (m, 2H).<\/p>\n

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 25016-20-0.<\/p>\n","protected":false},"excerpt":{"rendered":"

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 25016-20-0.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[242,131],"tags":[126],"class_list":["post-1884","post","type-post","status-publish","format-standard","hentry","category-25016-20-0","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe origin of a common compound about 25016-20-0<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25016-20-0, name is 1-Methyl-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C5H6N2O2\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1884\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The origin of a common compound about 25016-20-0\" \/>\n<meta property=\"og:description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25016-20-0, name is 1-Methyl-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The origin of a common compound about 25016-20-0","description":"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25016-20-0, name is 1-Methyl-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. 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