{"id":1845,"date":"2021-02-23T05:20:12","date_gmt":"2021-02-22T21:20:12","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1845"},"modified":"2021-02-23T05:20:12","modified_gmt":"2021-02-22T21:20:12","slug":"research-on-new-synthetic-routes-about-71229-85-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1845","title":{"rendered":"Research on new synthetic routes about 71229-85-1"},"content":{"rendered":"

Reference of 71229-85-1<\/a>, These common heterocyclic compound, 71229-85-1, name is 4-Bromo-1-ethyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

[0511j A solution of (6-bromo- i-ethyl-S -fluoro- 1 H-benzo [d]imidazol-2- yl)diphenylmethanol (0.21 g, 0.50 mmol), 4,4,4?,4?,S ,S ,S?,S?-octamethyl-2,2?-bi( 1,3,2- dioxaborolane) (0.25 g, 1.0 mmol), i,i?-bis(diphenylphosphino)ferrocenepalladium(II) dichloride (0.035 g, 0.050 mmol) and potassium acetate (0.098 g, 1.0 mmol) in dioxane (10 mL) was stirred at reflux for 5 hours. After cooling to ambient temperature, 4-bromo-i-ethyl- 1H-pyrazole (0.088 g, 0.5 mmol), tetrakis(triphenylphosphine)palladium (0) (0.055 g, 0.05 mmol), cesium carbonate (0.33 g, 1.0 mmol) and water (3 mL) were added. The reaction mixture was stirred at 100 C for 12 hours. After cooling to ambient temperature, ethyl acetate and water were added. The organic layer was separated, washed with brine, dried (sodium sulfate), filtered and concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel to give (i-ethyl-6-(i-ethyl-1H-pyrazol-4-yl)-5-fluoro- 1H-benzo[d]imidazol-2-yl)diphenylmethanol (0.10 g, 45%) as solid. LCMS ESI (+) mlz 441 (M+H).<\/p>\n

The synthetic route of 71229-85-1 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 71229-85-1 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[227,131],"tags":[126],"class_list":["post-1845","post","type-post","status-publish","format-standard","hentry","category-71229-85-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nResearch on new synthetic routes about 71229-85-1<\/title>\n<meta name=\"description\" content=\"Reference of 71229-85-1, These common heterocyclic compound, 71229-85-1, name is 4-Bromo-1-ethyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1845\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research on new synthetic routes about 71229-85-1\" \/>\n<meta property=\"og:description\" content=\"Reference of 71229-85-1, These common heterocyclic compound, 71229-85-1, name is 4-Bromo-1-ethyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1845\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-02-22T21:20:12+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1845\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1845\",\"name\":\"Research on new synthetic routes about 71229-85-1\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-02-22T21:20:12+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Reference of 71229-85-1, These common heterocyclic compound, 71229-85-1, name is 4-Bromo-1-ethyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1845#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=1845\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1845#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research on new synthetic routes about 71229-85-1\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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