{"id":1832,"date":"2021-02-22T05:08:09","date_gmt":"2021-02-21T21:08:09","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1832"},"modified":"2021-02-22T05:08:09","modified_gmt":"2021-02-21T21:08:09","slug":"discovery-of-141573-95-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1832","title":{"rendered":"Discovery of 141573-95-7"},"content":{"rendered":"

These common heterocyclic compound, 141573-95-7, name is Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate<\/a><\/p>\n

In a 100 mL reaction flask, add 1-methyl-3-difluoromethyl-1H-pyrazole-4-carboxylic acid ethyl ester (38 mmol) represented by formula (II), and then add 10% by mass NaOH30mL of aqueous solution, heated to 60 C and stirred until the reaction solution was transparent, then naturally cooled to room temperature,Acid was added to the reaction solution to adjust the pH to about 2.0, and a solid was precipitated.After the filter residue is washed and dried,1-methyl-3-difluoromethyl-1H-pyrazole-4-carboxylic acid represented by the formula (III) was obtained.<\/p>\n

The synthetic route of Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[187,131],"tags":[127],"class_list":["post-1832","post","type-post","status-publish","format-standard","hentry","category-141573-95-7","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nDiscovery of 141573-95-7<\/title>\n<meta name=\"description\" content=\"These common heterocyclic compound, 141573-95-7, name is Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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