{"id":1821,"date":"2021-02-22T05:08:09","date_gmt":"2021-02-21T21:08:09","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1821"},"modified":"2021-02-22T05:08:09","modified_gmt":"2021-02-21T21:08:09","slug":"research-on-new-synthetic-routes-about-1192-21-8-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1821","title":{"rendered":"Research on new synthetic routes about 1192-21-8"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1192-21-8, name is 1-Methyl-1H-pyrazol-5-amine, A new synthetic method of this compound is introduced below., Quality Control of 1-Methyl-1H-pyrazol-5-amine<\/a><\/p>\n

Example 1.26; Preparation of (4′-Fluoro-biphenyl-4-yI)-(2-methyl-2Eta-pyrazol-3-yl)-amine (Compound35). A 20-mL scintillation vial was charged with 4′-bromo-4-fluoro-biphenyl (251.1 mg, 1 mmol), 3 -amino-2 -methyl pyrazole (97.1 mg, 1 mmol), sodium terf-butoxide (134.5 mg, 1.4 , mmol), tris(dibenzylideneacetone)dipalladium(0) (45.8 mg, 0.05 mmol), BINuAP (62.3 mg, 0.1 mmol) and toluene (2 mL) under nitrogen atmosphere. The reaction mixture was heated at 800C for 48 hours. It was then allowed to cool to room temperature, taken up in ether\/ethyl acetate, filtered and concentrated. The crude material was subjected to column chromatography on silica gel (Biotage, eluent hexanes\/ethyl acetate 70\/30) to afford Compound 35 as a yellow solid. LCMS m\/z (percent) = 268 (M+H, 100).<\/p>\n

The synthetic route of 1192-21-8 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 1192-21-8 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[191,131],"tags":[145],"class_list":["post-1821","post","type-post","status-publish","format-standard","hentry","category-1192-21-8","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nResearch on new synthetic routes about 1192-21-8<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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