{"id":1813,"date":"2021-02-20T05:05:32","date_gmt":"2021-02-19T21:05:32","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1813"},"modified":"2021-02-20T05:05:32","modified_gmt":"2021-02-19T21:05:32","slug":"introduction-of-a-new-synthetic-route-about-120068-79-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1813","title":{"rendered":"Introduction of a new synthetic route about 120068-79-3"},"content":{"rendered":"

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 120068-79-3, name is 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 120068-79-3<\/a><\/p>\n

Example E4 5-Amino-3-cyano-4-(cyclohex-1-enyl)-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole A solution of 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl) pyrazole (1 g, the compound of Reference Example 1 from EP 295,117) and cyclohexanone (1.6 ml) in acetic acid (5 ml) was stirred and heated at 120 C. overnight under an atmosphere of nitrogen. The cooled reaction mixture was diluted with water and extracted with ethyl acetate and then ether. The combined organic extracts were washed with saturated aqueous sodium hydrogen carbonate solution, then water. After drying (MgSO4), evaporation gave the crude product which was purified by column chromatography on silica gel (50 g) eluted with dichloromethane:hexane (1:2), then dichloromethane:hexane (1:1). Combination and evaporation of appropriate fractions provided the title compound as a white solid m.p. 175-7 C. 1H-NMR (CDCl3) delta: 1.7 (m, 2H), 1.8 (m,2H), 2,2 (m, 2H), 2.45 (m, 2H), 3.74 (s, 2H), 5.9 (s, 1H), 7.78 (s, 2H) Microanalysis-found: C, 50.75, H. 3.07, N, 13.68%; C17H13Cl2F3N4 requires C,50.89, H, 3.27, N, 13.96%<\/p>\n

The synthetic route of 120068-79-3 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 120068-79-3 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[166,131],"tags":[167],"class_list":["post-1813","post","type-post","status-publish","format-standard","hentry","category-120068-79-3","category-pyrazoles-derivatives","tag-m-w300-400"],"yoast_head":"\nIntroduction of a new synthetic route about 120068-79-3<\/title>\n<meta name=\"description\" content=\"In the next few decades, the world population will flourish. 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