{"id":1809,"date":"2021-02-20T05:05:32","date_gmt":"2021-02-19T21:05:32","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1809"},"modified":"2021-02-20T05:05:32","modified_gmt":"2021-02-19T21:05:32","slug":"some-tips-on-152120-54-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1809","title":{"rendered":"Some tips on 152120-54-2"},"content":{"rendered":"

Related Products of 152120-54-2<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 152120-54-2 as follows.<\/p>\n

Compound 48 (200 mg), N,N?-bis(tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine (11) (420 mg) and diisopropylethylamine (0.12 mL) were dissolved in THF (4 mL). The mixture was stirred at room temperature for 12 h and then evaporated in vacuo. The residue was purified with silica gel chromatography (5% CHCl3\/MeOH) to give tert-butyl {(E)-({4-[2-(2-acetamido-5-{2-[4-(methylsulfonyl)phenyl]ethyl}-1,3-thiazol-4-yl)ethyl]phenyl}amino)[(tert-butoxycarbonyl)amino]methylene}carbamate (307 mg, 99%). tert-Butyl {(E)-({4-[2-(2-acetamido-5-{2-[4-(methylsulfonyl)phenyl]ethyl}-1,3-thiazol-4-yl)ethyl]phenyl}amino)[(tert-butoxycarbonyl)amino]methylene}carbamate (228 mg) was dissolved in 4 M HCl\/ dioxane (5 mL). The mixture was stirred at room temperature overnight and then evaporated in vacuo. The residue was triturated with AcOEt to give 49 (183 mg, 106%) as a white solid. 1H NMR (DMSO-d6) delta 2.16 (3H, s), 2.67 (4H, br s), 2.82-2.94 (4H, m), 3.14 (3H, s), 7.12 (2H, d, J = 8.4 Hz), 7.20 (2H, d, J = 8.4 Hz), 7.43 (2H, d, J = 8.4 Hz), 7.82 (2H, d, J = 8.4 Hz), 9.87 (1H, s), 11.97 (1H, s); FAB MS m\/e (M+H)+ 486; HRMS calcd for C23H28N5O3S2 (M+H)+: 486.1634, found: 486.1633.<\/p>\n

According to the analysis of related databases, 152120-54-2, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 152120-54-2, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[254,131],"tags":[167],"class_list":["post-1809","post","type-post","status-publish","format-standard","hentry","category-152120-54-2","category-pyrazoles-derivatives","tag-m-w300-400"],"yoast_head":"\nSome tips on 152120-54-2<\/title>\n<meta name=\"description\" content=\"Related Products of 152120-54-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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