{"id":1805,"date":"2021-02-20T05:05:32","date_gmt":"2021-02-19T21:05:32","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1805"},"modified":"2021-02-20T05:05:32","modified_gmt":"2021-02-19T21:05:32","slug":"some-tips-on-57012-20-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1805","title":{"rendered":"Some tips on 57012-20-1"},"content":{"rendered":"

Some common heterocyclic compound, 57012-20-1, name is (1,3-Dimethyl-1H-pyrazol-5-yl)methanol, molecular formula is C6H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of (1,3-Dimethyl-1H-pyrazol-5-yl)methanol<\/a><\/p>\n

71 a) To a stirring solution of (2,5-dimethyl-2H-pyrazol-3-yl)-methanol (100 mg, 0.79 mmol) in diethyl ether (3 mL) is added PBr3 (25 muL, 0.26 mmol). The reaction is stirred at room temperature for 18 hours, then water is added. The diethyl ether layer is separated and stored over solid NaOH and used in Step 71 b without further characterization. 71b) BEMP (137 pL, 0.47 mmol) is added to a solution of (2-methyl-1H-pyrrolo[2,3- b]pyridin-3-yl)-acetic acid methyl ester (60 mg, 0.29 mmol) in DMF (0.8 mL). After 35 minutes, the diethyl ether layer from Step 71 a (1.8 mL) is added. After 3 days, the reaction is partitioned between water and 1:1 EtOAc\/ether. The organic layer is washed with brine then evaporated. The residue is purified by flash column chromatography (49:1 EtOAc\/MeOH elution) to furnish [1-(2,5-dimethyl-2H-pyrazol-3-ylmethyl)-2-methyl-1H- pyrrolo[2,3-b]pyridin-3-yl]-acetic acid methyl ester; MH+ = 313.<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 57012-20-1, its application will become more common.<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 57012-20-1, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[371,131],"tags":[126],"class_list":["post-1805","post","type-post","status-publish","format-standard","hentry","category-57012-20-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSome tips on 57012-20-1<\/title>\n<meta name=\"description\" content=\"Some common heterocyclic compound, 57012-20-1, name is (1,3-Dimethyl-1H-pyrazol-5-yl)methanol, molecular formula is C6H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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Safety of (1,3-Dimethyl-1H-pyrazol-5-yl)methanol","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=1805","og_locale":"en_US","og_type":"article","og_title":"Some tips on 57012-20-1","og_description":"Some common heterocyclic compound, 57012-20-1, name is (1,3-Dimethyl-1H-pyrazol-5-yl)methanol, molecular formula is C6H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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