{"id":1778,"date":"2021-02-19T05:11:15","date_gmt":"2021-02-18T21:11:15","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1778"},"modified":"2021-02-19T05:11:15","modified_gmt":"2021-02-18T21:11:15","slug":"extended-knowledge-of-78208-72-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1778","title":{"rendered":"Extended knowledge of 78208-72-7"},"content":{"rendered":"

Related Products of 78208-72-7<\/a>, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 78208-72-7, name is Ethyl 3-isopropyl-1H-pyrazole-5-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.<\/p>\n

5-isopropyl-1H-pyrazol-3-carboxylic acid ethyl ester (18.9 g, 104 mmol) and 1M NaOH solution (260 mL, 259 mmol) were dissolved in 1,4-dioxane (300 mL), the reaction was heated to 50\u00a1\u00e3 C. under nitrogen and stirred for 3 h. The reaction mixture was cooled, adjusted to pH 2 using concentrated hydrochloric acid and the solvent was removed under reduced pressure. The residual solid was azeotroped with toluene (2.x.30 mL), dissolved in ethyl acetate (500 mL) and washed with water. The aqueous phase was removed, extracted with ethyl acetate (2.x.200 mL) and the combined organic extracts were dried over MgSO4. The solvent was removed under reduced pressure and the residue was azeotroped with dichloromethane (2.x.50 mL) to give the title product (14.7 g) as a white solid; 1H NMR (400 MHz, DMSO-D6): delta 12.50-13.30 (bs, 2H), 6.42 (s, 1H), 2.84-2.94 (quin, 1H), 1.15-1.19 (d, 6H) ppm; LRMS (electrospray): m\/z [M-H]+ 153.<\/p>\n

The chemical industry reduces the impact on the environment during synthesis Ethyl 3-isopropyl-1H-pyrazole-5-carboxylate. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"excerpt":{"rendered":"

The chemical industry reduces the impact on the environment during synthesis Ethyl 3-isopropyl-1H-pyrazole-5-carboxylate. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[372,131],"tags":[126],"class_list":["post-1778","post","type-post","status-publish","format-standard","hentry","category-78208-72-7","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nExtended knowledge of 78208-72-7<\/title>\n<meta name=\"description\" content=\"Related Products of 78208-72-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 78208-72-7, name is Ethyl 3-isopropyl-1H-pyrazole-5-carboxylate, This compound has unique chemical properties. 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