{"id":1776,"date":"2021-02-19T05:11:15","date_gmt":"2021-02-18T21:11:15","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1776"},"modified":"2021-02-19T05:11:15","modified_gmt":"2021-02-18T21:11:15","slug":"the-important-role-of-113100-53-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1776","title":{"rendered":"The important role of 113100-53-1"},"content":{"rendered":"

113100-53-1, name is 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid<\/a><\/p>\n

Example P5: Preparation of 1 -Methyl-3-trifluoromethyl-1 H-pyrazole-4-carboxylic acid (3-tert- butyl-2-vinylphenyl)amide; 197 mg (1 ,01 mmol) 1 -methyl-3-trifIuoromethyl-1 H-pyrazole-4-carboxyIic acid and 135 mg(1 ,07 mmol) oxalylic acid chloride are dissolved in 8 ml methylenechloride. The solution is stirred for 3 hours at room temperature in the presence of a catalytic amount of dimethylformamide (DMF). After this the solution is slowly added to a solution consisting of180 mg (1 ,01 mmol) 3-tert-butyl-2-vinyl-phenylamine, 155 mg (1 ,52 mmol) triethylamine and7 ml methylenechloride. The resulting reaction mixture is then stirred at room temperature for 16 hours. After removal of the solvent in a water jet vacuum, the residue is purified by flash chromatography over silicagel (eluent: hexane\/ethylacetate 2:1). This gives 0,27 g 1- methyl-3-trifluoromethyl-1 H-pyrazole-4-carboxylic acid (3-tert-butyl-2-vinylphenyl)amide in the form of a colourless solid (m.p. 118-119C; 76% of theory).<\/p>\n

The synthetic route of 113100-53-1 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 113100-53-1 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[195,131],"tags":[126],"class_list":["post-1776","post","type-post","status-publish","format-standard","hentry","category-113100-53-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of 113100-53-1<\/title>\n<meta name=\"description\" content=\"113100-53-1, name is 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 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