{"id":1765,"date":"2021-02-18T05:48:17","date_gmt":"2021-02-17T21:48:17","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1765"},"modified":"2021-02-18T05:48:17","modified_gmt":"2021-02-17T21:48:17","slug":"research-on-new-synthetic-routes-about-81945-73-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1765","title":{"rendered":"Research on new synthetic routes about 81945-73-5"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 81945-73-5, name is 1H-Pyrazol-1-ol, This compound has unique chemical properties. The synthetic route is as follows., name: 1H-Pyrazol-1-ol<\/a><\/p>\n

1. N-2-[4-(1,1-Dimethylethoxy)phenoxy]ethoxypyrazole A solution of 12.7 g (0.15 mol) of N-hydroxypyrazole in 20 ml of DMF was added dropwise to a suspension of 4.95 g (1.1 eq.) of NaH (80% dispersion in mineral oil) in 40 ml of DMF at RT, and the mixture was heated at 70 C. for 1 h. A solution of 40.95 g (0.15 mol) of 2-[4-(1,1-dimethylethoxy)phenoxy]ethyl bromide in 100 ml of DMF was added and the mixture was then heated at 125 C. for 15 h. The solvent was then stripped off in a rotary evaporator, the residue was taken up in ethyl acetate, and the solution was washed twice each with 5% strength NaOH solution and water. Drying and removal of the solvent under reduced pressured resulted in 38.4 g (93%) of the required compound as a pale oil which was employed without further purification in the next stage. 1 H-NMR (250 MHz, CDCl3): delta=7.38 (d, 1H); 7.28 (d, 1H); 6.93 (d, 2H); 6.83 (d, 2H); 6.17 (t, 1H); 4.63 (m, 2H); 4.17 (m, 2H); 1.30 (s, 9H) ppm<\/p>\n

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 81945-73-5.<\/p>\n","protected":false},"excerpt":{"rendered":"

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 81945-73-5.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[369,131],"tags":[145],"class_list":["post-1765","post","type-post","status-publish","format-standard","hentry","category-81945-73-5","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nResearch on new synthetic routes about 81945-73-5<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 81945-73-5, name is 1H-Pyrazol-1-ol, This compound has unique chemical properties. 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