{"id":1761,"date":"2021-02-18T05:48:17","date_gmt":"2021-02-17T21:48:17","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1761"},"modified":"2021-02-18T05:48:17","modified_gmt":"2021-02-17T21:48:17","slug":"simple-exploration-of-578008-32-9","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1761","title":{"rendered":"Simple exploration of 578008-32-9"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 578008-32-9, name is tert-Butyl 3-amino-5-methyl-1H-pyrazole-1-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 578008-32-9, HPLC of Formula: C9H15N3O2<\/a><\/p>\n

A reaction vessel was charged with 6-chloro-N-[(l\u00a1\u00ea)-l-(5-fluoropyrimidm-2-yl)emyl]pyrazm-2- amine (Intermediate 9, 118 mg, 0.47 mmol), tert-butyl 3-amino-5-methyl-lH-pyrazole-l- carboxylate (Intermediate 10, 103 mg, 0.52 mmol), Cs2CO3 (459 mg, 1.14 mmol), Xantphos (14 mg, 0.024 mmol) and Pd2(dba)3 (7 mg, 0.012 mmol) and purged with nitrogen for 10 minutes. Dioxane (0.15 M) was then added to the tube and the reaction mixture was purged with nitrogen for another 10 minutes. The reaction mixture was heated at 1000C overnight. The reaction mixture was filtered through a plug of diatomaceous earth, diluted with EtOAc, washed with nuaetaCO3(aq) and brine, and dried (Na2SO4). The solvent was removed in vacuo to give a yellow residue (181 mg), which was purified with a Gilson column (10-35% MeCN\/H2O, 15 min). The title compound was collected as a yellow solid (18.9 mg). LCMS: [M+H]+ 315. 1H NMR (300 MHz5 DMSO-d6) delta: 9.69 (s, 1 H) 8.94 (s, 2 H) 7.77 (br.s, 1 H) 7.53 (s, 1 H) 7.43 (s, 1 H) 6.03 (s, 1 H) 5.68 (s, 1 H) 5.24 (m, 1 H) 2.27 (s, 3 H) 1.60 (d, 3 H).<\/p>\n

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"excerpt":{"rendered":"

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[330,131],"tags":[126],"class_list":["post-1761","post","type-post","status-publish","format-standard","hentry","category-578008-32-9","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSimple exploration of 578008-32-9<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 578008-32-9, name is tert-Butyl 3-amino-5-methyl-1H-pyrazole-1-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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