{"id":1759,"date":"2021-02-18T05:48:17","date_gmt":"2021-02-17T21:48:17","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1759"},"modified":"2021-02-18T05:48:17","modified_gmt":"2021-02-17T21:48:17","slug":"discovery-of-1146629-77-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1759","title":{"rendered":"Discovery of 1146629-77-7"},"content":{"rendered":"

Some common heterocyclic compound, 1146629-77-7, name is (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, molecular formula is C15H17N5O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C15H17N5O2<\/a><\/p>\n

Step 6. (+\/-)-(4-(1 -(2-Cyano- 1 -(2,2,5,5 -d4-cyclopentyl)ethyl)- 1 H-pyrazol-4- yl)-7H-pyrrolol2,3-dlpyrimidin-7-yl)methyl pivalate ((+\/-)38). To a solution of 37 (400 mg, 1.34 mmol, preparation described in Lin, Q. et al. Org. Lett., 2009, 1], 1999-2002) in acetonitrile (10 mL) was added 36 (418 mg, 3.34 mmol) followed by DBU (421 tL, 2.81 mmol). The reaction stirred at room temperature for 15 hours then was concentrated under reduced vacuum. The resulting crude mixture was diluted with water and extracted with ethyl acetate (3 x 50 mL). The organic layers were combined, washed with iN HC1, dried (Na2SO4), filtered and concentrated underreduced pressure. Purification via normal phase column chromatography (Si02, 0-60% ethyl acetate\/hexanes) followed by reverse phase column chromatography (C 18, 5-70% acetonitrile\/water containing 0.1% formic acid) afforded (+\/-)38 (68 mg, 12%) as a white foam. 1H NMR (DMSO-d6, 400 MHz) oe 8.84 (s, 1H), 8.79 (s, 1H),8.40 (s, 1H), 7.74 (d, J= 3.8 Hz, 1H), 7.12 (d, J- 3.8 Hz, lH), 6.24 (s, 2H), 4.54 (td, J= 9.7, 4.3 Hz, 1H), 3.30-3.15 (m, 2H), 2.39 (d, J 9.8 Hz, 1H), 1.68- 1.36 (m, 4H), 1.08 (s, 9H); MS (ESI) 425.3 [(M + H)j.<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1146629-77-7, its application will become more common.<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1146629-77-7, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[360,131],"tags":[127],"class_list":["post-1759","post","type-post","status-publish","format-standard","hentry","category-1146629-77-7","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nDiscovery of 1146629-77-7<\/title>\n<meta name=\"description\" content=\"Some common heterocyclic compound, 1146629-77-7, name is (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, molecular formula is C15H17N5O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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