{"id":1750,"date":"2021-02-10T05:17:53","date_gmt":"2021-02-09T21:17:53","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1750"},"modified":"2021-02-10T05:17:53","modified_gmt":"2021-02-09T21:17:53","slug":"discovery-of-718632-46-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1750","title":{"rendered":"Discovery of 718632-46-3"},"content":{"rendered":"

These common heterocyclic compound, 718632-46-3, name is 5-tert-Butyl 2-ethyl 3-amino-6,6-dimethylpyrrolo[3,4-c]pyrazole-2,5(4H,6H)-dicarboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 5-tert-Butyl 2-ethyl 3-amino-6,6-dimethylpyrrolo[3,4-c]pyrazole-2,5(4H,6H)-dicarboxylate<\/a><\/p>\n

Example 5; Preparation of 6,6-dimethyi-3-[4-(4-methyl-piperazin-1-yl)-2-nitro-benzoylamino]- 4H,6H-pyrrolo|;3,4-c]pyrazole-2,5-d.carboxylic acid 5-tert-butyl ester 2-thetathyl ester; 4-(4-rnethyip1perazin-1-yl)-2-nitro-ben;-oic acid (15 g, 49,7 mmol) in dry tetrahydrofuran (100 mL) was stirred with thionyl chloride (5 eq ., 18,1 mL, 2487 mmol) and a few drops of N,N-dimethyiformamide at 8QC for about 14 hours . After removal of the solvent under vacuum, the crude material was added portion-wise to a solution of 3-amino-6,6- dimethy.-4H,6H-pyrro.o[3,4~c]pyrazo.e-2,5-d.carboxytic acid 5-tert-butyl ester 2-ethyl ester (16 t g, 49 7 mmol) and IM.N-diethyiisopropylatnine (5 eq , 43 4 mL, 248 7 mmol} in 1 ,4- dioxane (200 mL) maintained under magnetic stirring at 80C The reaction mixture was stirred for about 6 hours at 80C After removal of the solvent, the crude material was diluted with dichloromethane (200 mL), washed with saturated sodium hydrogen carbonate solution (200 mL), dried over sodium sulphate, evaporated to dryness and purified by flash chromatography on sittca gel using acetone as the efuant. The titfe compound was obtained as light yellow powder (13 5 g, 47% yield). 1 H-NMR (400 MHz), 3. (ppm, DMSOd6): 10 70, 10 67{s, 1 H)1 7 68, 7 66 (d, J1 =8 78Hz, 1 H), 7 48(bs, I H), 7.30 (dd, J 1=8 78 Hz, J2=2.56 Hz, 1 H)1 4 47-4.39 (m, 4H), 3,41 (m, 4H), 2.52 (m, 4H), 2 27 (s, 3H), 1,63, 1 62 (s, 6H), 1.49, 1 46 (s, 9H)1 137, 1 36 (t, J=7 07 Hz1 3H); mixture of rotamers<\/p>\n

The synthetic route of 5-tert-Butyl 2-ethyl 3-amino-6,6-dimethylpyrrolo[3,4-c]pyrazole-2,5(4H,6H)-dicarboxylate has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 5-tert-Butyl 2-ethyl 3-amino-6,6-dimethylpyrrolo[3,4-c]pyrazole-2,5(4H,6H)-dicarboxylate has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[368,131],"tags":[167],"class_list":["post-1750","post","type-post","status-publish","format-standard","hentry","category-718632-46-3","category-pyrazoles-derivatives","tag-m-w300-400"],"yoast_head":"\nDiscovery of 718632-46-3<\/title>\n<meta name=\"description\" content=\"These common heterocyclic compound, 718632-46-3, name is 5-tert-Butyl 2-ethyl 3-amino-6,6-dimethylpyrrolo[3,4-c]pyrazole-2,5(4H,6H)-dicarboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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