{"id":1718,"date":"2021-02-09T05:19:50","date_gmt":"2021-02-08T21:19:50","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1718"},"modified":"2021-02-09T05:19:50","modified_gmt":"2021-02-08T21:19:50","slug":"a-new-synthetic-route-of-1146629-77-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1718","title":{"rendered":"A new synthetic route of 1146629-77-7"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1146629-77-7, name is (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, A new synthetic method of this compound is introduced below., Application In Synthesis of (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate<\/a><\/p>\n

The production of tert-butyl-3-(cyanomethyl)-3-[4-(7-{[(2,2- dimethylpropanoyl)oxy] methyl}-7H-pyrrolo[2,3 -d]pirimidin-4-yl)- lH-pyrazol-1-yl] azetidine-1-carboxylate of formula (I) 6.49 ml (6.6 g; 43.43 mmol; 0.5 equ.) of l l,8-diazabicyclo[5.4.0]-undec-7-ene (DBU) is added drop by drop at room temperature to a suspension of 26.00 g (86.87 mmol) of 4-(lH-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pirimidin-7-yl]methyl 2,2-dimethylpropanoate of formula (X) and 16.87 g (86.87 mmol) of ieri-butyl 3-(cyanomethylidene)azetidine-l-carboxylate of formula (IV) made with 520 ml of acetonitrile. The reaction mixture is stirred for 2 hours at room temperature, then for a further 2 hours at 0-5 C. The precipitated solid material is filtered, then washed on the filter with 2×25 ml of 5 C acetonitrile, then dried at room temperature and atmospheric pressure until constant weight is achieved. In this way 38.8 g (90.0%) of a white solid product is obtained, the purity of which measured with LC MS at 254 nm is 99.8%.Mp. 181.0-183.5 C. IR (KBr): 1739, 1693, 1585, 1380,1124. HNMR (DMSO-ifc, 500 MHz): 8.94 (s, 1H), 8.82 (s, 1H), 8.48 (s, 1H), 7.76 (d, J=3.7 Hz, 1H), 7.22 (d, J=3.8 Hz, 1H), 6.26 (s, 2H), 4.53 (d, J=8.9 Hz, 2H), 4.24 (d, J=9.4 Hz, 2H), 3.68 (s, 2H), 1.42 (s, 9H), 1.10 (s, 9H). CNMR (DMSO-ifc, 125 MHz): 177.16, 155.52, 151.70, 151.69, 150.34, 140.01, 130.14, 130.06, 121.66, 116.94, 113.61, 101.41, 79.60, 66.68, 58.62, 57.05, 26.98, 26.70. Element analysis calculating for the formula theta5Eta3iotaNu704 (M: 493.57); C 60.84%; H 6.33%; N 19.86%.Measured: C 60.39%; H 6.25%; N 19.88%<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[360,131],"tags":[127],"class_list":["post-1718","post","type-post","status-publish","format-standard","hentry","category-1146629-77-7","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nA new synthetic route of 1146629-77-7<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1146629-77-7, name is (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, A new synthetic method of this compound is introduced below., Application In Synthesis of (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=1718\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A new synthetic route of 1146629-77-7\" \/>\n<meta property=\"og:description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"A new synthetic route of 1146629-77-7","description":"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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