{"id":1702,"date":"2021-02-08T05:02:59","date_gmt":"2021-02-07T21:02:59","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1702"},"modified":"2021-02-08T05:02:59","modified_gmt":"2021-02-07T21:02:59","slug":"introduction-of-a-new-synthetic-route-about-100784-27-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1702","title":{"rendered":"Introduction of a new synthetic route about 100784-27-8"},"content":{"rendered":"

Some common heterocyclic compound, 100784-27-8, name is Methyl 3-chloro-1-methyl-5-sulfamoyl-1H-pyrazole-4-carboxylate, molecular formula is C6H8ClN3O4S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of Methyl 3-chloro-1-methyl-5-sulfamoyl-1H-pyrazole-4-carboxylate<\/a><\/p>\n

To a mixture of 7.0 g of 3-chloro-4-methoxycarbonyl-1-methylpyrazole-5-sulfonamide, 5.3 g of anhydrous potassium carbonate and 50 ml of dry acetone there was added 2.8 g of n-butyl isocyanate at room temperature, and the mixture was refluxed for 3 hours. After the reaction, acetone was evaporated under reduced pressure and the residue was dissolved in ice-water. After separation of a trace of water insolubles, the filtrate was made acidic with hydrochloric acid and the crystals formed were filtered, washed with water and dried to give 5.2 g of N-(n-butylcarbamoyl)-3-chloro-4-methoxycarbonyl-1-methlpyrazole-5-sulfonamide. (0065) Into a mixture of 120 ml of dry toluene and the product obtained from the above procedure, 4.2 g of phosgene was passed under reflux. Then, the reaction mixture was further refluxed for 1.5 hours. After completion of the reaction, evaporation under reduced pressure to obtain crude 3-chloro-4-ethoxycarbonyl-1-methylpyrazole-5-sulfonyl isocyanate.<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 100784-27-8, its application will become more common.<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 100784-27-8, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[355,131],"tags":[127],"class_list":["post-1702","post","type-post","status-publish","format-standard","hentry","category-100784-27-8","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nIntroduction of a new synthetic route about 100784-27-8<\/title>\n<meta name=\"description\" content=\"Some common heterocyclic compound, 100784-27-8, name is Methyl 3-chloro-1-methyl-5-sulfamoyl-1H-pyrazole-4-carboxylate, molecular formula is C6H8ClN3O4S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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