{"id":1685,"date":"2021-02-07T05:53:05","date_gmt":"2021-02-06T21:53:05","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1685"},"modified":"2021-02-07T05:53:05","modified_gmt":"2021-02-06T21:53:05","slug":"analyzing-the-synthesis-route-of-92933-47-6","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1685","title":{"rendered":"Analyzing the synthesis route of 92933-47-6"},"content":{"rendered":"

These common heterocyclic compound, 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C7H10N2O2<\/a><\/p>\n

Example 1. Synthesis of 5-(propan-2-yl)-N-{4-[(pyrimidin-2- yl)sulfamoyl]phenyl}-lH-pyrazole-3-carboxamide, 1-17 1-17 [00265] HATU (460mg, 1.2 mmol) and DIPEA (0.42 ml, 2.4 mmol) were added at Rt to a stirred solution of 3-(propan-2-yl)-lH-pyrazole-5-carboxylic acid (120mg, 0.8 mmol) in DMF (HPLC grade, 7 ml) followed by 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide (200mg, 0.8 mmol). The resulting mixture was stirred at Rt for 20h. The solvent was removed in vacuo and the remaining material was purified by prep HPLC (MeCN\/Water, 0.1% formic acid) to afford lOmg (3%) of 5-(propan-2-yl)-N-{4-[(pyrimidin-2-yl)sulfamoyl]phenyl}-lH-pyrazole-3- carboxamide 1-17 as a colourless solid. 1H NMR (500 MHz, DMSO-d6) delta 13.15 (s, 1H), 10.29 (s, 1H), 8.48 (d, J = 4.8 Hz, 2H), 7.98 (d, J = 8.6 Hz, 2H), 7.91 (d, J = 8.6 Hz, 2H), 7.01 (s, 1H), 6.54 (s, 1H), 3.11 – 2.77 (m, 1H), 1.25 (d, J = 6.9 Hz, 6H).<\/p>\n

The synthetic route of 5-Isopropyl-1H-pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 5-Isopropyl-1H-pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[352,131],"tags":[126],"class_list":["post-1685","post","type-post","status-publish","format-standard","hentry","category-92933-47-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nAnalyzing the synthesis route of 92933-47-6<\/title>\n<meta name=\"description\" content=\"These common heterocyclic compound, 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C7H10N2O2\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=1685\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Analyzing the synthesis route of 92933-47-6\" \/>\n<meta property=\"og:description\" content=\"These common heterocyclic compound, 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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