{"id":1680,"date":"2021-02-07T05:53:05","date_gmt":"2021-02-06T21:53:05","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1680"},"modified":"2021-02-07T05:53:05","modified_gmt":"2021-02-06T21:53:05","slug":"introduction-of-a-new-synthetic-route-about-95162-14-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1680","title":{"rendered":"Introduction of a new synthetic route about 95162-14-4"},"content":{"rendered":"

Related Products of 95162-14-4<\/a>, A common heterocyclic compound, 95162-14-4, name is 4-Bromo-1-tritylpyrazole, molecular formula is C22H17BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

Step 2) Synthesis of 4- (4-fluorophenyl) -1-trityl-lH- pyrazole To a suspension of 4-bromo-trityl-l.H-pyrazole (0.7 g) in N, N-dimethylformamide (14 ml) was added 4- fluorophenylboronic acid (0.377 g) , cesium carbonate (1.758 g) , and tetrakis triphenylphosphine palladium (0.208 g) . The resulting suspension was stirred at room temperature for 10 min. The irradiation of microwaves at 1600C for 10 min was sufficient to complete a reaction in the suspension. The product was filtered through silica gel, diluted in ethyl acetate (30 ml) and washed with saturated ammonium chloride solution (30 ml) and then with brine (30 ml) . The washed organic layer thus formed was dried over anhydrous magnesium sulfate and concentrated by evaporation in a vacuum. The residue thus obtained was separated using silica gel chromatography to produce 4- (4-fluorophenyl) -1- trityl-lH-pyrazole (yield 51%) .1H-NMROOOMHZ, CDCl3): 57.93 (s, IH), 7.62 (s, IH), 7.36-7.29(m, HH), 7.21-7.18(m, 6H).<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[252,131],"tags":[167],"class_list":["post-1680","post","type-post","status-publish","format-standard","hentry","category-95162-14-4","category-pyrazoles-derivatives","tag-m-w300-400"],"yoast_head":"\nIntroduction of a new synthetic route about 95162-14-4<\/title>\n<meta name=\"description\" content=\"Related Products of 95162-14-4, A common heterocyclic compound, 95162-14-4, name is 4-Bromo-1-tritylpyrazole, molecular formula is C22H17BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1680\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Introduction of a new synthetic route about 95162-14-4\" \/>\n<meta property=\"og:description\" content=\"Related Products of 95162-14-4, A common heterocyclic compound, 95162-14-4, name is 4-Bromo-1-tritylpyrazole, molecular formula is C22H17BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1680\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-02-06T21:53:05+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1680\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1680\",\"name\":\"Introduction of a new synthetic route about 95162-14-4\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-02-06T21:53:05+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Related Products of 95162-14-4, A common heterocyclic compound, 95162-14-4, name is 4-Bromo-1-tritylpyrazole, molecular formula is C22H17BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1680#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=1680\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1680#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Introduction of a new synthetic route about 95162-14-4\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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