{"id":1678,"date":"2021-02-07T05:53:05","date_gmt":"2021-02-06T21:53:05","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1678"},"modified":"2021-02-07T05:53:05","modified_gmt":"2021-02-06T21:53:05","slug":"the-important-role-of-34334-96-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1678","title":{"rendered":"The important role of 34334-96-8"},"content":{"rendered":"

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 34334-96-8 as follows. Safety of 3-Methyl-5-nitro-1H-pyrazole<\/a><\/p>\n

In a sealed tube, 2-(tributylphosphoranylidene)-acetonitrile (7.30 g, 30.25 mmol) was added to a solution of 5-Methyl-3-nitro-lH-pyrazole (2.00 g, 15.74 mmol) and 2- cyclopropylethanol (2.04 g, 23.68 mmol) in toluene (70 mL). The mixture was heated at 60 C for 19 h. After cooling down to rt, the mixture was diluted with EtOAc and water. The organic layer was decanted and the solvent was evaporated in vacuo. The residue was purified by column chromatography on silica gel (Irregular SiOH, 20-45 muiotaeta, 40 g, mobile phase: heptane\/EtOAc, gradient from 60:40 EtOAc to 50:50). The pure fractions were combined and the solvent was evaporated until dryness to give 2.10 g of intermediate 232′ (68% yield) and 330 mg of intermediate 232 (11% yield).<\/p>\n

According to the analysis of related databases, 34334-96-8, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 34334-96-8, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[324,131],"tags":[126],"class_list":["post-1678","post","type-post","status-publish","format-standard","hentry","category-34334-96-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of 34334-96-8<\/title>\n<meta name=\"description\" content=\"In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 34334-96-8 as follows. 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