{"id":1658,"date":"2021-02-05T03:09:31","date_gmt":"2021-02-04T19:09:31","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1658"},"modified":"2021-02-05T03:09:31","modified_gmt":"2021-02-04T19:09:31","slug":"introduction-of-a-new-synthetic-route-about-57999-06-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1658","title":{"rendered":"Introduction of a new synthetic route about 57999-06-1"},"content":{"rendered":"

Related Products of 57999-06-1<\/a>, A common heterocyclic compound, 57999-06-1, name is 4-Phenyl-1H-pyrazol-5-amine, molecular formula is C9H9N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

To a mixture of ethyl-2-benzyl-3-oxo-butanoate ( 100 rng, 454.01 muetaiotaomicron, 96.15 mu^, 1.00 eq) and 4-phenyl-lH-pyrazol-5-amine (80 mg, 499.41 wmol, 1.10 eq) in EtOH (5 mL) was added H3PQ4 (98 mg, 454.01 iotaetaomicron, 50.00 ,uL, 85% v\/v, 1 .00 eq). Then the reaction mixture was stirred at 100 C for 16 h. LC-MS indicated the desired product was detected. Water ( 10 mL) was added and the mixture was stirred at 5 C for 1 h. Then the mixture was filtered and the filter cake was dried in vacuo to give 6-benzyl-5-methyl-3-phenyl- pyrazolo[l,5-a]pyrimidin-7-ol (65.3 mg, 195.92 mutaueta, 43% yield) as a white solid. NMR (400 MHz, DMSO-ifc) delta 1 1.79 (brs, I I I ). 8.12 (s, 1H), 7.57 (d, J = 7.6, 2H), 7.46 (t, 2H), 7.34-7.26 (m, 6H), 3.89 (s, 2H), 2.39 (s, 3H); I3C NMR (100 MHz, DMSQ-tfc) delta 157.4, 148.7, 142,6, 140.8, 137.3, 131.3, 129,3, 128.8, 128.4, 127.9, 126,9, 126.3, 106.0, 104 ,4, 30.5, 1 7.6, LC-MS (ESI): m\/z 316.0 ( i } .<\/p>\n

The synthetic route of 57999-06-1 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 57999-06-1 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[347,131],"tags":[126],"class_list":["post-1658","post","type-post","status-publish","format-standard","hentry","category-57999-06-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nIntroduction of a new synthetic route about 57999-06-1<\/title>\n<meta name=\"description\" content=\"Related Products of 57999-06-1, A common heterocyclic compound, 57999-06-1, name is 4-Phenyl-1H-pyrazol-5-amine, molecular formula is C9H9N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=1658\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Introduction of a new synthetic route about 57999-06-1\" \/>\n<meta property=\"og:description\" content=\"Related Products of 57999-06-1, A common heterocyclic compound, 57999-06-1, name is 4-Phenyl-1H-pyrazol-5-amine, molecular formula is C9H9N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"http:\/\/www.pyrazoles-derivatives.com\/?p=1658\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-02-04T19:09:31+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=1658\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=1658\",\"name\":\"Introduction of a new synthetic route about 57999-06-1\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-02-04T19:09:31+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Related Products of 57999-06-1, A common heterocyclic compound, 57999-06-1, name is 4-Phenyl-1H-pyrazol-5-amine, molecular formula is C9H9N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=1658#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/www.pyrazoles-derivatives.com\/?p=1658\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=1658#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Introduction of a new synthetic route about 57999-06-1\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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