{"id":1639,"date":"2021-02-03T05:01:30","date_gmt":"2021-02-02T21:01:30","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1639"},"modified":"2021-02-03T05:01:30","modified_gmt":"2021-02-02T21:01:30","slug":"application-of-35344-95-7-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1639","title":{"rendered":"Application of 35344-95-7"},"content":{"rendered":"

Synthetic Route of 35344-95-7<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35344-95-7 as follows.<\/p>\n

2-((3,5-dicyano-4-ethyl-6-(piperazin-1-yl)pyridin-2-yl)thio)-2-phenylacetamide trifluoroacetic acid (synthesis described in example 176 step 2, 215 mg, 0.413 mmol) was dissolved in dichloromethane (15 mL) and DIEA (0.144 mL, 0.826 mmol). Acetic acid (0.047 mL, 0.826 mmol) was added followed by 1H-pyrazole-4-carbaldehyde (79 mg, 0.826 mmol) The reaction was stirred for 30 minutes and sodium triacetoxyborohydride (350 mg, 1.652 mmol) was added. The reaction was stirred at 25 \u00a1\u00e3C for 18Hous. The DCM solution was washed with water, a solution of saturated sodium bicarbonate, and then water. The DCM solution was dried then evaporated and the resulting solid was triturated with ethyl acetate to give after filtration pure product. The solid was dried in vacuum oven overnight to afford 2-((6-(4-((1H-pyrazol-4-yl)methyl)piperazin-1-yl)-3,5- dicyano-4-ethylpyridin-2-yl)thio)-2-phenylacetamide (75 mg, 0.149 mmol, 36percent yield) LCMS m\/z = 487.2 [M+H]+. 1H NMR (400 MHz, DMSO-d6) delta ppm 1.20 (t, J=7.60 Hz, 3 H) 2.44 (br. s., 4 H) 2.75 (d, J=7.60 Hz, 2 H) 3.44 (s, 2 H) 3.86 (d, J=4.82 Hz, 4 H) 5.52 (s, 1 H) 7.28 – 7.44 (m, 4 H) 7.46 – 7.61 (m, 5 H) 7.91 (s, 1 H).<\/p>\n

According to the analysis of related databases, 35344-95-7, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 35344-95-7, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[154,131],"tags":[145],"class_list":["post-1639","post","type-post","status-publish","format-standard","hentry","category-35344-95-7","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nApplication of 35344-95-7<\/title>\n<meta name=\"description\" content=\"Synthetic Route of 35344-95-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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