{"id":1626,"date":"2021-02-02T03:25:26","date_gmt":"2021-02-01T19:25:26","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1626"},"modified":"2021-02-02T03:25:26","modified_gmt":"2021-02-01T19:25:26","slug":"research-on-new-synthetic-routes-about-14521-80-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1626","title":{"rendered":"Research on new synthetic routes about 14521-80-3"},"content":{"rendered":"

Synthetic Route of 14521-80-3<\/a>, A common heterocyclic compound, 14521-80-3, name is 3-Bromo-1H-pyrazole, molecular formula is C3H3BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

Step 2. tert-butyl 4-(3-bromo-lH-pyrazol-l-yl)piperidine-l-carboxylate (Intermediate 17) and tert-butyl 4-(5-bromo-lH-pyrazol-l-yl)piperidine-l-carboxylate (Intermediate 18) [0258] A mixture of tert-butyl 4-(methylsulfonyloxy)piperidine-l -carboxylate (0.837 g, 3.00 mmol), 3-bromo-lH-pyrazole (0.441 g, 3.02 mmol), and cesium carbonate (2.94 g, 9.02 mmol) in DMF (10 mL) stirred for 5 h at 100 C. The reaction mixture was cooled to room temperature and poured ethyl acetate (50 mL). The mixture was washed with water (3 x 10 mL), dried over anhydrous sodium sulfate, filtered, and concentrated under vacuum. The residue purified via column chromatography on silica gel (eluting with 10% dichloromethane\/methanol to afford tert-butyl 4-(3- bromo-lH-pyrazol-l-yl)piperidine-l -carboxylate (0.25 g, 25%) as a white solid. MS (ESI, pos. ion) m\/z 330,332 [M+H]+. [0259] tert-butyl 4-(5-bromo-lH-pyrazol-l-yl)piperidine-l -carboxylate (0.150 g, 15%) was also obtained as a white solid. MS (ESI, pos. ion) m\/z 330,332 [M+H]+.<\/p>\n

The synthetic route of 14521-80-3 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 14521-80-3 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[180,131],"tags":[126],"class_list":["post-1626","post","type-post","status-publish","format-standard","hentry","category-14521-80-3","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nResearch on new synthetic routes about 14521-80-3<\/title>\n<meta name=\"description\" content=\"Synthetic Route of 14521-80-3, A common heterocyclic compound, 14521-80-3, name is 3-Bromo-1H-pyrazole, molecular formula is C3H3BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1626\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research on new synthetic routes about 14521-80-3\" \/>\n<meta property=\"og:description\" content=\"Synthetic Route of 14521-80-3, A common heterocyclic compound, 14521-80-3, name is 3-Bromo-1H-pyrazole, molecular formula is C3H3BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1626\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-02-01T19:25:26+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1626\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1626\",\"name\":\"Research on new synthetic routes about 14521-80-3\",\"isPartOf\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-02-01T19:25:26+00:00\",\"author\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Synthetic Route of 14521-80-3, A common heterocyclic compound, 14521-80-3, name is 3-Bromo-1H-pyrazole, molecular formula is C3H3BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1626#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=1626\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1626#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"http:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research on new synthetic routes about 14521-80-3\"}]},{\"@type\":\"WebSite\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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