{"id":1553,"date":"2021-01-25T06:56:15","date_gmt":"2021-01-24T22:56:15","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1553"},"modified":"2021-01-25T06:56:15","modified_gmt":"2021-01-24T22:56:15","slug":"application-of-119022-51-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1553","title":{"rendered":"Application of 119022-51-4"},"content":{"rendered":"

These common heterocyclic compound, 119022-51-4, name is 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3(2H)-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3(2H)-one<\/a><\/p>\n

Step 1 : Synthesis of 4-bromo-l-methyl-5-(trifluoromethyl)-2,3-dihydro-lH-pyrazol- 3-one: [01064] To a stirred solution of l-methyl-5-(trifluoromethyl)-lH-pyrazol-3-ol (2g, 12.0 mmol) in ethanol (15 mL) was added bromine (0.74 mL, 14.5 mmol). The resulting solution was stirred at room temperature overnight. After which time, the reaction was concentrated in vacuo and the residue was basified (pH 8) with a saturated aqueous solution of sodium hydrogen carbonate (20 mL). The product was extracted with DCM (5×15 mL) and the combined organics were washed with brine (20 mL). The aqueous phase was back-extracted with DCM (2×5 mL). The combined organics were dried over MgS04, filtered and concentrated in vacuo to afford the title compound as an off white solid (2.48 g, 83% yield), which was used directly in the next step without purification. LC-MS 99%, 1.69 min (3 minute LC-MS method), m\/z=244.80, 246.85, XH NMR (500 MHz, Methanol-d4) delta 3.81 (d, J = 1.1 Hz, 3H).<\/p>\n

The synthetic route of 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3(2H)-one has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3(2H)-one has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[311,131],"tags":[126],"class_list":["post-1553","post","type-post","status-publish","format-standard","hentry","category-119022-51-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nApplication of 119022-51-4<\/title>\n<meta name=\"description\" content=\"These common heterocyclic compound, 119022-51-4, name is 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3(2H)-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3(2H)-one\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1553\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Application of 119022-51-4\" \/>\n<meta property=\"og:description\" content=\"These common heterocyclic compound, 119022-51-4, name is 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3(2H)-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3(2H)-one\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1553\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-01-24T22:56:15+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1553\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1553\",\"name\":\"Application of 119022-51-4\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-01-24T22:56:15+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"These common heterocyclic compound, 119022-51-4, name is 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3(2H)-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3(2H)-one\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1553#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=1553\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=1553#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Application of 119022-51-4\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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