{"id":1537,"date":"2021-01-21T02:52:14","date_gmt":"2021-01-20T18:52:14","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1537"},"modified":"2021-01-21T02:52:14","modified_gmt":"2021-01-20T18:52:14","slug":"new-downstream-synthetic-route-of-5334-40-7-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1537","title":{"rendered":"New downstream synthetic route of 5334-40-7"},"content":{"rendered":"

Application of 5334-40-7<\/a>, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.<\/p>\n

Into a 50 mL round bottom flask containing a solution of 4-nitro-7H-pyrrazole-3-carboxalic acid (5.0 g, 32 mmol) in methanol (50 mL) was added concentrated sulfuric acid (1 mL) at 0 C. The resulting slurry was stirred at reflux temperature overnight. The solvents were evaporated under reduced pressure and the residual mass was dissolved in ethyl acetate and washed with water and brine solution. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated to yield methyl 4-nitro-7H-pyrazole-3-carboxylate as a solid which was taken to next step without further purification. 1Eta NMR (CD3OD 300 MHz): delta 8.59 (s, 1H), 3.93 (s, 3H). MS calc’d [M-H]+ 170.0, found 170.1.<\/p>\n

The chemical industry reduces the impact on the environment during synthesis 4-Nitro-1H-pyrazole-3-carboxylic acid. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"excerpt":{"rendered":"

The chemical industry reduces the impact on the environment during synthesis 4-Nitro-1H-pyrazole-3-carboxylic acid. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[153,131],"tags":[126],"class_list":["post-1537","post","type-post","status-publish","format-standard","hentry","category-5334-40-7","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nNew downstream synthetic route of 5334-40-7<\/title>\n<meta name=\"description\" content=\"Application of 5334-40-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1537\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New downstream synthetic route of 5334-40-7\" \/>\n<meta property=\"og:description\" content=\"Application of 5334-40-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. 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