{"id":1522,"date":"2021-01-20T02:43:19","date_gmt":"2021-01-19T18:43:19","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1522"},"modified":"2021-01-20T02:43:19","modified_gmt":"2021-01-19T18:43:19","slug":"the-origin-of-a-common-compound-about-1190380-49-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1522","title":{"rendered":"The origin of a common compound about 1190380-49-4"},"content":{"rendered":"

Related Products of 1190380-49-4<\/a>, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1190380-49-4 name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.<\/p>\n

To a 100 ml flask were added methyl 2,4-dichloro-6-methylpyrimidine-5-carboxylate (309 mg, 1.4 mmol), 1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-amine (234 mg, 1.4 mmol), 10 ml of acetonitrile and DIPEA (0.54 g, 4.18 mmol). The reaction mixture was stirred at 40 C. for 1 h, acetonitrile was evaporated under reduced pressure and then 30 ml of EtOAc was added. The mixture was washed with 60 ml of water and 30 ml of brine. The organic phase was dired and concentrated to give 405 mg of intermediate 7a as a grey solid. MS m\/z (ESI): 352.1[M+H]+.<\/p>\n

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, and friends who are interested can also refer to it.<\/p>\n","protected":false},"excerpt":{"rendered":"

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[210,131],"tags":[126],"class_list":["post-1522","post","type-post","status-publish","format-standard","hentry","category-1190380-49-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe origin of a common compound about 1190380-49-4<\/title>\n<meta name=\"description\" content=\"Related Products of 1190380-49-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1190380-49-4 name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=1522\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The origin of a common compound about 1190380-49-4\" \/>\n<meta property=\"og:description\" content=\"Related Products of 1190380-49-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1190380-49-4 name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The origin of a common compound about 1190380-49-4","description":"Related Products of 1190380-49-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1190380-49-4 name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"http:\/\/www.pyrazoles-derivatives.com\/?p=1522","og_locale":"en_US","og_type":"article","og_title":"The origin of a common compound about 1190380-49-4","og_description":"Related Products of 1190380-49-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1190380-49-4 name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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