{"id":1517,"date":"2021-01-20T02:43:19","date_gmt":"2021-01-19T18:43:19","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1517"},"modified":"2021-01-20T02:43:19","modified_gmt":"2021-01-19T18:43:19","slug":"analyzing-the-synthesis-route-of-2033-45-6","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1517","title":{"rendered":"Analyzing the synthesis route of 2033-45-6"},"content":{"rendered":"

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2033-45-6, name is 3,5-Dimethyl-4-iodopyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 3,5-Dimethyl-4-iodopyrazole<\/a><\/p>\n

To a stirred degassed solution of 4-iodo-3,5-dimethyl-1 H-pyrazole (500 mg, 2.25 mmol) in DMF (5 mL) was added Zn(CN)2 (141 .2 mg, 1 .58 mmol) followed by Pd(dppf)CI2 (82.4 mg, 0.1 1 mmol) and Zn-dust (7.4 mg, 0.1 1 mmol) under inert atmosphere. Resulting mixture was heated at 100C for 4 hours. After completion, the reaction mixture was diluted with cold water and extracted with ethyl acetate. Combined organic layer was washed with water, brine, dried over sodium sulphate, filtered, and concentrated under reduced pressure. Crude compound was purified by column chromatography (30%-50% ethyl acetate-hexane) to afford 3,5-dimethyl-1 H- pyrazole-4-carbonitrile (120 mg, 44%) as light brown solid.<\/p>\n

The synthetic route of 2033-45-6 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 2033-45-6 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[316,131],"tags":[127],"class_list":["post-1517","post","type-post","status-publish","format-standard","hentry","category-2033-45-6","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nAnalyzing the synthesis route of 2033-45-6<\/title>\n<meta name=\"description\" content=\"In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2033-45-6, name is 3,5-Dimethyl-4-iodopyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 3,5-Dimethyl-4-iodopyrazole\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1517\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Analyzing the synthesis route of 2033-45-6\" \/>\n<meta property=\"og:description\" content=\"In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2033-45-6, name is 3,5-Dimethyl-4-iodopyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. 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