{"id":1499,"date":"2021-01-18T07:21:49","date_gmt":"2021-01-17T23:21:49","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1499"},"modified":"2021-01-18T07:21:49","modified_gmt":"2021-01-17T23:21:49","slug":"research-on-new-synthetic-routes-about-287922-71-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1499","title":{"rendered":"Research on new synthetic routes about 287922-71-8"},"content":{"rendered":"

Synthetic Route of 287922-71-8<\/a>, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 287922-71-8, name is 4-Bromo-1-methyl-1H-pyrazole-3-carbonitrile, This compound has unique chemical properties. The synthetic route is as follows.<\/p>\n

To a solution of tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indoline-l-carboxylate (1,8 g, 5.32 mmol) in dioxane (20 mL) and H20 (4 mE) was added K2C03 (2 g,14.52 mmol), [1,1 -bis(diphenylphosphino)ferrocene]dichEoropal1adium(I1) (350 mg, 0.5 mmol) and 4-bromo-1-methyl-IH-pyrazole-3-carbonitrile (0.9 g, 4.84 mmol). The mixture was heated to 120 C for 12 h under a nitrogen atmosphere. After cooling the reaction to room temperature, the mixture was concentrated in vacuo. The crude residue was purified bysilica gel chromatography (petroleum ether \/ EtOAc 1: 1) to give the title compound (1.13 g, 70%) as yellow solid. LCMS M\/Z (M+H-t-Bu) 269.<\/p>\n

The chemical industry reduces the impact on the environment during synthesis 4-Bromo-1-methyl-1H-pyrazole-3-carbonitrile. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"excerpt":{"rendered":"

The chemical industry reduces the impact on the environment during synthesis 4-Bromo-1-methyl-1H-pyrazole-3-carbonitrile. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[305,131],"tags":[126],"class_list":["post-1499","post","type-post","status-publish","format-standard","hentry","category-287922-71-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nResearch on new synthetic routes about 287922-71-8<\/title>\n<meta name=\"description\" content=\"Synthetic Route of 287922-71-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 287922-71-8, name is 4-Bromo-1-methyl-1H-pyrazole-3-carbonitrile, This compound has unique chemical properties. The synthetic route is as follows.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1499\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research on new synthetic routes about 287922-71-8\" \/>\n<meta property=\"og:description\" content=\"Synthetic Route of 287922-71-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 287922-71-8, name is 4-Bromo-1-methyl-1H-pyrazole-3-carbonitrile, This compound has unique chemical properties. 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