{"id":1492,"date":"2021-01-15T05:10:36","date_gmt":"2021-01-14T21:10:36","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1492"},"modified":"2021-01-15T05:10:36","modified_gmt":"2021-01-14T21:10:36","slug":"new-downstream-synthetic-route-of-180207-57-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1492","title":{"rendered":"New downstream synthetic route of 180207-57-2"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 180207-57-2, name is 2-(1H-Pyrazol-4-yl)ethanol, This compound has unique chemical properties. The synthetic route is as follows., Formula: C5H8N2O<\/a><\/p>\n

General procedure: KMnO4 (42.7 g, 0.27 mol) was added in small portions to asolution (in case of compounds 4a-c) or suspension (incase of compound 4d) of alcohol 4 (0.1 mol) and K2CO3 (5 g)in H2O (200 ml) at 70 during 1 h. The mixture washeated with stirring at 80 for 3 h, cooled to room temperature, and the precipitate that formed was filtered off. The mother liquid was acidified by 0.1 M aq HCl topH 5. The precipitated product was filtered and dried atroom temperature in vacuo. 2-Oxo-2-(1H-pyrazol-4-yl)acetic acid (13a). Yield10.6 g (76%). Colorless solid. Mp >280C. 1H NMR spectrum (DMSO-d6), delta, ppm (J, Hz): 8.02 (1H, s, H-5);8.17 (1H, s, H-3). 13C NMR spectrum (DMSO-d6), delta, ppm:119.8 (C-4); 136.5 (C-3); 137.6 (C-5); 164.3 (CO); 185.8(COOH). Mass spectrum (APCI), m\/z: 139 [M-H]-. Found, %:C 42.72; H 2.82; N 20.14. C5H4N2O3. Calculated, %:C 42.87; H 2.88; N 20.00.<\/p>\n

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 180207-57-2.<\/p>\n","protected":false},"excerpt":{"rendered":"

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 180207-57-2.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[211,131],"tags":[126],"class_list":["post-1492","post","type-post","status-publish","format-standard","hentry","category-180207-57-2","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nNew downstream synthetic route of 180207-57-2<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 180207-57-2, name is 2-(1H-Pyrazol-4-yl)ethanol, This compound has unique chemical properties. 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