{"id":1487,"date":"2021-01-15T05:10:36","date_gmt":"2021-01-14T21:10:36","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=1487"},"modified":"2021-01-15T05:10:36","modified_gmt":"2021-01-14T21:10:36","slug":"the-important-role-of-3524-32-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=1487","title":{"rendered":"The important role of 3524-32-1"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3524-32-1, name is 5-Amino-1,3-dimethylpyrazole, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C5H9N3<\/a><\/p>\n

The following crystalline form was characterised:2-(2-Chloro-5 -(trifluoromethyl)pyridin-4-ylamino)-6-methoxy-N-methylbenzamide (1.66 g, 4.61 mmol), l,3-dimethylpyrazol-5-amine (0.523 g, 4.71 mmol), palladium(II) acetate (0.083 g, 0.37 mmol), 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene (0.427 g, 0.74 mmol) and cesium carbonate (1.804 g, 5.54 mmol) were mixed together in dioxane (30 mL). The reaction was degassed with argon and was stirred at 90 0C for 3 hours under argon. The mixture was filtered, the filtrate concentrated and purified twice by flash chromatography on silica gel eluting with 0 to 4% MeOH in DCM\/EtOAc (60:40). The solvent was evaporated to dryness to afford 2-(2-( 1,3 -dimethyl- lH-pyrazol-5 -ylamino)-5- (trifluoromethyl)pyridin-4-ylamino)-6-methoxy-N-methylbenzamide (0.882 g, 44.0 %) as a beige solid. 150 mg of this material was dissolved in acetonitrile, concentrated and diluted with DCM. Crystals appeared slowly. The resulting crystalline solid was collected by filtration, washed with DCM and dried to a constant weight to afford 2-[[2-[(2,5- dimethylpyrazol-3-yl)amino]-5-(trifluoromethyl)-4-pyridyl]amino]-6-methoxy-N-methyl- benzamide (110 mg, 32.3 %) as a white crystalline solid. Melting onset of 163C<\/p>\n

According to the analysis of related databases, 3524-32-1, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 3524-32-1, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[139,131],"tags":[126],"class_list":["post-1487","post","type-post","status-publish","format-standard","hentry","category-3524-32-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of 3524-32-1<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3524-32-1, name is 5-Amino-1,3-dimethylpyrazole, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C5H9N3\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=1487\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The important role of 3524-32-1\" \/>\n<meta property=\"og:description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3524-32-1, name is 5-Amino-1,3-dimethylpyrazole, This compound has unique chemical properties. 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